The University of Texas System

Immunesensor Therapeutics, Inc.

Millennium Pharmaceuticals Limited

Immune Sensor, LLC

Zhijian Chen

Lijun Sun

Chuo Chen

Heping Shi

Qi Wei

Youtong Wu

Jian Qiu

Boyu Zhong

Jiaxi Wu

Matt Tschantz

Jing Li

Huiling Tan

Yuanwei Dai

Jinming Gao

Gang Huang

Yang-Xin Fu

Zhaohui Wang

Rashu Seth Bhargava

Xiao-Dong Li

Hua Wang

Hulling Tan

Min Luo

Haocheng Cai

The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

Antibody-sting agonist conjugates and their use in immunotherapy

The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Quinoline cGAS antagonist compounds

Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

cGAS antagonist compounds

CGAS antagonist compounds

Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2'3-cGAMP, 2&#x2032;2-cGAMP, 3&#x2032;2&#x2032;-cGAMP and 3&#x2032;3&#x2032;-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway

In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

Sting activating nanovaccine for immunotherapy

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Cyclic di-nucleotide compounds and methods of use

Antibody-STING agonist conjugates and their use in immunotherapy

Growing community of inventors

Dallas, TX, United States of America

Zhijian Chen