University of Florida Research Foundation, Incorporated

The State University of New York

Zhihui Yang

Kevin Ka-Wang Wang

Richard Rubenstein

Kevin K Wang

Ahmed Moghieb

Yasmeen O Elmelige

Joseph A Tyndall

Karl Wilhelm Huesgen

A method is provided for predicting a neurological outcome of a patient post-cardiac arrest. The method includes obtaining, on a processor, first data that indicates values for two or more neurological biomarkers collected from the patient during a first time period following a cardiac arrest. The method also includes obtaining, on the processor, subsequent data that indicates values for the two or more neurological biomarkers collected at a subsequent time period after the first time period following the cardiac arrest. The method also includes determining, on the processor, third data that indicates a prediction of a neurological outcome of the patient during a treatment of the patient based on the first data and the subsequent data. A system is also provided for using a composite score that is formed with the combined use of the values for two or more biomarkers making a prediction of a neurological outcome of a patient post-cardiac arrest.

Method and apparatus for prediciting neurological outcome post-cardiac arrest

Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (CNS injury) including traumatic brain injury (TBI), traumatic spinal cord injury (SCI) and chronic traumatic encephalopathy (CTE). Time course measurements post CNS-injury of these proteins can be used to monitor progress or recovery over periods up to several months. Differentiation of acute, subacute and chronic injury can be diagnosed by comparing the protein levels in CNS-injury patients at days 1-3, day 4-10 with levels at day 30-180 in comparison with normal controls.

Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system

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Gainesville, FL, United States of America

Zhihui Yang