Genentech, Inc.

Xenon Pharmaceuticals Inc.

Dell Products Inc.

Zhiguo Liu

Daniel P Sutherlin

Christoph Martin Dehnhardt

Brian Salvatore Safina

Sultan Chowdhury

Daniel Fred Ortwine

Jun M Li

Shaoyi Sun

Thilo Focken

Alla Yurevna Zenova

Qi Jia

Michael Edward Grimwood

Ivan William Hemeon

Kwong Wah Lai

Jiuxiang Zhu

Andrew D White

Tao Wang

Jun Liang

Michael Scott Wilson

Jean-Christophe Andrez

Steven McKerrall

Paul Robert Bichler

John Wai

Shannon Marie Decker

Abid Hasan

Tao Sheng

Chien-An Chen

Fei Wang

Nicholas Charles Ray

Steven Huy Do

Xiaojing Wang

Sharada Shenvi Labadie

Birong Zhang

Claudio F Sturino

Simon Charles Goodacre

Naomi S Rajapaksa

Kristen Nicole Burford

Jason R Zbieg

Joy Drobnick

Marian C Bryan

Philippe Bergeron

Alberto Gobbi

Ramsay Beveridge

Yongsheng Chen

James Richard Kiefer, Jr

Jean-Philippe Leclerc

Wei Gong

Liqiang Fu

Wenfeng Liu

Alexandre Lemire

Liang Zhao

Jiangpeng Liao

Tamiko Katsumoto

Tommy Lai

Teresa Phuongtram Nguyen

Hui Cao

An apparatus comprises at least one processing device configured to deploy, at a given one of a plurality of information technology assets in an information technology infrastructure environment, an instance of a self-managed information technology asset configuration tool. The at least one processing device is also configured to determine, utilizing the instance of the self-managed information technology asset configuration tool deployed on the given information technology asset, a logical dispatch order for performing configuration operations for at least one of the plurality of information technology assets in the information technology infrastructure environment, wherein the logical dispatch order operates recursively across two or more levels of a processing hierarchy. The at least one processing device is further configured to perform, utilizing the instance of the self-managed information technology asset configuration tool deployed on the given information technology asset, the configuration operations in accordance with the determined logical dispatch order.

Self-managed configuration of information technology assets in an information technology environment

Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators

The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative: 

Therapeutic compounds and methods of use thereof

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure:  and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Growing community of inventors

Shanghai, China

Zhiguo Liu