Metabolix, Inc.

Cj Research Center LLC

Zhigang Zhang

Oliver P Peoples

Thomas Martin Ramseier

Kristi D Snell

Johan Van Walsem

Jihong Tang

Nii Patterson

Jixiang Han

Karen Bohmert-Tatarev

Christopher W J McChalicher

Richard P Eno

Venkata Tavva

Andrew Hertig

Disclosed are organisms genetically engineered to make useful products when grown on ethanol as a carbon source. The organisms are genetically engineered to produce various useful products such as polyhydroxyalkanoates, diols, diacids, higher alcohols, and other useful chemicals.

Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock

Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ('PHA') are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ('PHB'). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.

Generation of high polyhydroxybutyrate producing oilseeds

Growing community of inventors

Watertown, MA, United States of America

Zhigang Zhang