Shanghai Hengrui Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceuticals Co., Ltd.

Aba Chemicals (nantong) Limited

Zhigang Lin

Takuya Matsumoto

Fuqiang Zhao

Wei Zhang

Peng Cho Tang

Fanglong Yang

Hejun Lü

Guangyuan Shen

Dongliang Guan

Jianghong Fu

Yueheng Jiang

Hejun Lu

Tong Cai

Pengcho Tang

Jianhong Fu

Provided is a method of preparing 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid by air oxidation. The methoduses 3-fluoroalkyl-1-substituted pyrazol-4-formaldehyde as raw material for reaction in a neutral or alkaline condition under the action of a catalyst and with air as an oxidizing agent, to obtain 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid. The method employs a mild, safe and clean reaction, and is suitable for industrial mass production.

Method of preparing 3-fluoroalkyl-1 substituted pyrazol-4-carboxylic acid by air oxidation

The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description. 

Dicycloazaalkane derivatives, preparation processes and medical uses thereof

Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification. 

Dicycloazaalkane derivates, preparation processes and medical uses thereof

Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.

Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV

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Zhigang Lin