3m Innovative Properties Company

Solventum Intellectual Properties Company

Zhicheng Tian

Robert A Asmus

James Patrick DiZio

Ying Zhang

Jason W Bjork

Jonathan J O'Hare

Patrick J Parks

Amy S Determan

Brian E Spiewak

Kheng Vang

Encai Hao

Zhaohui Yang

Dong-Wei Zhu

Junkang Jacob Liu

James P DiZio

Kent C Hackbarth

James Dizio

Jonathan J O'HARE

Antimicrobial compositions containing an antimicrobial agent, such as an octenidine salt, a solubilizer, such as a glycol, and a cidatrope, such as a C-Calcohol, an ether, an amide, an ester, and combinations thereof, where the compositions are substantially free of water and C-Calcohols and methods of making such antimicrobial compositions.

Antimicrobial composition

Adhesive compositions are disclosed that include an octenidine salt, a resin system, a plasticizer, and a cidatrope. The dried adhesive compositions are substantially free of water and C-Calcohols. The adhesive compositions disclosed are formulations that provide rapid and persistent antimicrobial activity and may be useful, for example, in wound dressings, surgical drapes, and medical tapes.

Adhesive compositions

Phase separated articles that include a matrix phase including an acrylate copolymer; and a silicone elastomer phase stably dispersed in the matrix phase are described. The matrix phase may be derived from precursors comprising from 60 to 95 parts by weight of an alkyl acrylate having an alkyl group having 1 to 14 carbon atoms. Methods of forming phase separated articles, and articles including phase separated articles are also described.

Phase separated articles

Provided is a method of forming a fibrin hydrogel composition, the method including providing a fibrin hydrogel or precursor thereof, comprising fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further includes combining the fibrin hydrogel with a carrier material. The concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrin hydrogel.

Fibrin composition comprising carrier material, method and wound articles

Provided is a method of forming a fibrinogen hydrogel composition, the method including providing a fibrinogen hydrogel or precursor thereof, comprising fibrinogen hydrogel forming salt. The fibrinogen hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrinogen hydrogel. The method further includes denaturing the fibrinogen hydrogel such as by heating. The method optionally further includes combining the fibrinogen hydrogel with a carrier material. When present, the concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrinogen hydrogel.

Fibrinogen composition, method and wound articles

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Woodbury, MN, United States of America

Zhicheng Tian