Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Zhibin Xu

Lei Zhang

Weikang Tao

Lianshan Zhang

Xin Ye

Xiangdong Qu

Piaoyang Sun

Qiyue Hu

Guoqing Cao

Jijun Yuan

Dongbing Cui

Shaoyu Xu

Bei Yuan

Kan Chen

The present invention provides a PCSK9 antibody, an antigen-binding fragment thereof, and a medicinal application thereof. Provided in the invention is a chimeric antibody and a humanized antibody, both comprising a CDR of the PCSK9 antibody, and a pharmaceutical composition comprising the PCSK9 antibody and an antigen-binding fragment thereof, and an application of the PCSK9 antibody as a lipid-lowering agent. The invention specifically relates to an application of a humanized PCSK9 antibody for preparing a pharmaceutical drug to treat a PCSK9-induced disease or symptom.

PCSK9 antibody, antigen-binding fragment thereof, and medical application thereof

Provided is an IL-15 heterodimeric protein, such as an IL-15/IL-15R&#x3b1; heterodimeric protein. The IL-15 heterodimeric protein contains protein (I) and protein (II). Protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant, and protein (II) is a second Fc variant, or recombinantly produced by combining IL-15R&#x3b1; or a variant thereof with a second Fc variant. The first Fc variant and the second Fc variant are preferably linked via a 'Knob-into-Hole' mode. Also provided are methods of using the IL-15 heterodimeric proteins to modulate an immune response. The provided IL-15 heterodimeric proteins have significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to the IL-15 molecule alone.

IL-15 heterodimeric protein and uses thereof

Growing community of inventors

Shanghai, China

Zhibin Xu