Shenzhen Sunxing Light Alloys Materials Co., Ltd.

Guangzhou Medical University

Zhi Zhou

Jun Yang

Xuemin Chen

Yueming Yu

Qingdong Ye

Xinyi Chen

Wei Yi

Sihai Zhou

Ronald Ray Duckworth

Qingchao Wang

Du Feng

Junyuan Tang

Yongquan Hu

Haixia Zhuang

The present application belongs to the technical field of proteolysis-targeting chimeras (PROTACs), and discloses a PROTAC molecule and a preparation method and use thereof. A ligand for a target protein in the PROTAC molecule of the present application is a pyridine carboxylic acid-1-oxide derivative. In cell and zebrafish experiments, the PROTAC molecule exhibits no toxic and side effects at a drug concentration allowing a desired effect. At a cellular level, an inhibition level of the PROTAC molecule for human tyrosinase (TYR) reaches less than or equal to 1 μmol/L. The PROTAC molecule in the present application can significantly reduce the generation of melanin by degrading TYR, and has excellent solubility, safety, and efficacy and a low effective concentration.

Proteolysis-targeting chimera molecule and preparation method and use thereof

Disclosed are a silicon-aluminum alloy and its preparation method. The method comprises: adding aluminum metal or molten aluminum into a container, wherein the temperature of the molten aluminum is between 700° C. and 800° C.; adding a semi-metallic silicon raw material to the molten aluminum, closing a furnace cover, carrying out vacuumization, and introducing argon, to ensure that the interior of a magnetic induction furnace is in a positive-pressure state, and stirring the aluminum metal or molten aluminum with a graphite stirring head; powering on and heating so that the aluminum metal or molten aluminum is heated to 1000° C. or above and molten, and holding the temperature between 1000° C. and 1500° C.; and after alloying is completed, cooling the molten aluminum to 1000° C. or below, opening the furnace cover, pouring the silicon-aluminum alloy into a corresponding mold, and cooling for molding.

Silicon-aluminum alloy and preparation method therefor

The present invention provides a zero pollution recovery system for safely producing anhydrous fluorine hydride, comprising: a compartment, a reactor for producing fluorine hydride, and a water pool; the reactor is disposed in the compartment; the water pool is disposed at the bottom of the compartment; absorption hoods are respectively disposed above both ends of the reactor for absorbing fluorine hydride gas; at least two absorption towers mutually connected in series via pipes are disposed above the compartment; water pipes connected with the water pool are respectively disposed at the top and bottom of the absorption tower; and a cooler and a receiver connected with the water pool is disposed on the pipes. The present invention has the advantages of being able to control the range over which fluorine hydride can diffuse.

Zero pollution recovery system for safely producing anhydrous fluorine hydride

The present invention provides a process for producing sponge titanium, which includes the following steps: Step A: placing aluminum into a resistance furnace, vacuum pumping, introducing inert gas, heating to molten aluminum; Step B: opening a reactor cover, adding a proper amount of potassium fluotitanate to a reactor, leakage detecting after closing the reactor cover, slowly raising the temperature to 150&#xb0; C., vacuum pumping, and continuously heating to 250&#xb0; C.; Step C: introducing inert gas into the reactor, continuously raising the temperature to 750&#xb0; C., stirring uniformly; Step D: opening a valve to adjust the stirring speed, adding molten aluminum drops, and controlling the reaction temperature to 750&#xb0; C. to 850&#xb0; C.; Step E: opening the reactor cover, removing a stirring device, eliminating the upper layer of KAlFto obtain sponge titanium. The present invention has the beneficial effects of short process flow, low cost, environmental protection and harmlessness.

Process for producing sponge titanium

The invention provides a technological method for preparing sponge titanium from sodium fluotitanate raw material, comprising the following steps: step A: placing aluminum in an airtight resistance furnace, evacuating, introducing inert gas into the resistance furnace, and heating the aluminum to obtain molten aluminum; step B: opening a reactor cover, adding a proper amount of sodium fluotitanate into the reactor, closing the reactor cover, detecting leakage, slowly heating the reactor to 150&#xb0; C., evacuating and continuously heating the reactor to 250&#xb0; C.; step C: introducing inert gas into the reactor, continuously heating the reactor to 900&#xb0; C., and stirring uniformly; step D: opening a valve, adjusting the stirring speed, dripping the molten aluminum, and controlling the temperature of reaction in a range from 900 to 1000&#xb0; C.; and step E: opening the reactor cover, removing a stirring device out of the reactor, and eliminating NaAlFat upper layer to obtain sponge titanium.

Technological method for preparing sponge titanium from sodium fluotitanate raw material

The invention provides a method for preparing sponge titanium from potassium fluotitanate by aluminothermic reduction, comprising the following steps: a reaction step: aluminum and zinc are mixed under a vacuum state, and the mixture is then reacted with potassium fluotitanate; a distillation step: KF, AlFand Zn generated by reaction are distilled out under a vacuum state; and a cooling step: sponge titanium is obtained subsequent to banking cooling. The invention further provides another method for preparing sponge titanium from potassium fluotitanate by aluminothermic reduction, comprising the following steps: a reaction step: aluminum and magnesium are mixed under a vacuum argon introduction condition, and the mixture is then reacted with potassium fluotitanate; a distillation step: KF, AlF, MgFand Mg generated by reaction are distilled out under a vacuum state; and a cooling step: sponge titanium is obtained subsequent to banking cooling.

Method for preparing sponge titanium from potassium fluotitanate by aluminothermic reduction

The invention provides a method for preparing sponge titanium from sodium fluotitanate by aluminothermic reduction, comprising the following steps: a reaction step: aluminum and zinc are mixed under a vacuum state, and sodium fluotitanate is then added into the mixture for reaction; a separation step: the product resulting from the complete reaction stands still and is then introduced with inert gas, and NaF and AlFin upper-layer liquid phase are extracted; and a distillation step: Zn in the remaining product Zn&#x2014;Ti is distilled out under a vacuum state, wherein the mass ratio of the aluminum to the zinc is 1:2 to 1:10.

Method for preparing sponge titanium from sodium fluotitanate by aluminothermic reduction

A method for cyclically preparing titanium sponge and coproducing sodium cryolite using sodium fluotitanate as an intermediate material, which includes the following steps: A) adding hydrofluoric acid to titaniferous iron concentrate to enable a reaction to form fluotitanic acid; B) adding sodium carbonate and sodium hydroxide to the fluotitanic acid to enable a reaction to form the sodium fluotitanate; C) putting the sodium fluotitanate into a reactor, adding aluminum to react with the sodium fluotitanate to form the titanium sponge and sodium cryolite; D) extracting the sodium cryolite and sending it to a rotary reaction kettle together with concentrated sulphuric acid to enable a reaction to form hydrogen fluoride gas and sodium sulphate, aluminum sodium sulphate; collecting the hydrogen fluoride gas and dissolving it into water to obtain a hydrofluoric acid solution; E) recycling the obtained hydrofluoric acid to Step A to leach the titaniferous iron concentrate.

Method for cyclically preparing titanium sponge and coproducing sodium cryolite using sodium fluotitanate as intermediate material

A method for cyclically preparing titanium sponge and coproducing potassium cryolite using potassium fluotitanate as an intermediate material, which includes the following steps: A) adding hydrofluoric acid to titaniferous iron concentrate to enable a reaction to form fluotitanic acid; B) adding potassium sulphate to the fluotitanic acid to enable a reaction to form the potassium fluotitanate; C) putting the potassium fluotitanate into a reactor, adding aluminum to react with the potassium fluotitanate to form the titanium sponge and potassium cryolite; D) extracting the potassium cryolite and sending it to a rotary reaction kettle together with concentrated sulphuric acid to enable a reaction to form hydrogen fluoride gas and potassium sulphate, aluminum potassium sulphate; collecting the hydrogen fluoride gas and dissolving it into water to obtain a hydrofluoric acid aqueous solution; E) recycling the obtained hydrofluoric acid aqueous solution to Step A to leach the titaniferous iron concentrate.

Method for cyclically preparing titanium sponge and coproducing potassium cryolite using potassium fluotitanate as intermediate material

A cyclic preparation method including the following steps: a) boric acid or boric anhydride is added with hydrofluoric acid and then with potassium sulfate for reaction to generate potassium fluoborate; titanium-iron concentrate is added with hydrofluoric acid and then with potassium sulfate for reaction to generate potassium fluotitanate; B) the potassium fluoborate is mixed with the potassium fluotitanate, and the mixture reacts with aluminum to generate titanium boride and potassium cryolite; C) the potassium cryolite is sucked out and then fed into a rotary reaction kettle together with concentrated sulfuric acid, hydrogen fluoride gas as well as potassium sulfate and potassium aluminum sulfate are generated by reaction in the rotary reaction kettle, and the hydrogen fluoride gas is collected and then dissolved in water to obtain hydrofluoric acid aqueous solution; and D) the obtained hydrofluoric acid aqueous solution and potassium sulfate aqueous solution are recycled.

Cyclic preparation method for producing titanium boride from intermediate feedstock potassium-based titanium-boron-fluorine salt mixture and producing potassium cryolite as byproduct

A cyclic preparation method for producing titanium boride from intermediate feedstock sodium-based titanium-boron-fluorine salt mixture and producing sodium cryolite as byproduct, which comprises the steps: a) boric acid or boric anhydride is added with hydrofluoric acid and then with sodium carbonate solution for concentration and crystallization to generate sodium fluoborate; titanium-iron concentrate is added with hydrofluoric acid and then with sodium carbonate and sodium hydroxide to obtain sodium fluotitanate; B) the sodium fluoborate is mixed with the sodium fluotitanate, and the mixture reacts with aluminum to generate titanium boride and sodium cryolite; C) the sodium cryolite is sucked out and then fed into a rotary reaction kettle together with concentrated sulfuric acid, hydrogen fluoride gas as well as sodium sulfate and sodium aluminum sulfate are generated by reaction in the rotary reaction kettle, and the hydrogen fluoride gas is collected and then dissolved in water to obtain hydrofluoric acid aqueous solution; and D) the obtained hydrofluoric acid aqueous solution is recycled.

Cyclic preparation method for producing titanium boride from intermediate feedstock sodium-based titanium-boron-fluorine salt mixture and producing sodium cryolite as byproduct

A method for cyclically preparing monomer boron and coproducing potassium cryolite using potassium fluoborate as an intermediate material, which includes following steps: A) adding hydrofluoric acid to boric acid or boron oxide to enable a reaction to form fluoboric acid; B) adding a potassium sulphate aqueous solution to the fluoboric acid to enable a reaction to form the potassium fluoborate; C) putting the potassium fluoborate into a reactor, adding aluminium to react with the potassium fluoborate to form the monomer boron and potassium cryolite; D) extracting the potassium cryolite, sending the potassium cryolite to a rotary reaction kettle together with concentrated sulphuric acid to enable a reaction to form hydrogen fluoride gas and aluminium potassium sulphate, potassium sulphate, collecting the hydrogen fluoride gas and dissolving it into water to obtain the hydrofluoric acid; E) recycling the obtained hydrofluoric acid to Step A to leach the boric acid or boron oxide.

Method for cyclically preparing monomer boron and coproducing potassium cryolite using potassium fluoborate as intermediate material

A method for cyclically preparing elemental boron and coproducing sodium cryolite using sodium fluoborate as an intermediate material, which includes the following steps: A) adding hydrofluoric acid to boric acid or boron oxide to enable a reaction to form fluoboric acid; B) adding a sodium carbonate aqueous solution to the fluoboric acid to enable a reaction to form the sodium fluoborate; C) putting the sodium fluoborate into a reactor, adding aluminum to react with the sodium fluoborate to form the elemental boron and sodium cryolite; D) extracting the sodium cryolite, sending the sodium cryolite to a rotary reaction kettle together with concentrated sulphuric acid to enable a reaction to form hydrogen fluoride gas and aluminum sodium sulphate, collecting the hydrogen fluoride gas and dissolving it into water to obtain the hydrofluoric acid; E) recycling the obtained hydrofluoric acid to Step A to leach the boric acid or boron oxide.

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Guangdong, China

Zhi Zhou