Florida State University Research Foundation, Inc.

Other

Proda Biotech LLC

Liu, Zhi-ren

Li, Liangwei

Zhang, Yinwei

Zhi-Ren Liu

Jenny Jie Yang

Yin Lu

Shenghui Xue

Jenny Y Yang

Jie Yang

Bing Xu

Wangda Zhou

Liangwei Li

Randolph L Rill

Yinwei Zhang

Haizhen Wang

Liangeiwei Li

Chakra Ravi Turaga

Jenny J Yang

Systems and methods for promoting cellular regeneration in ischemic tissue through administration of pyruvate kinase M2 or a substantially similar therapeutic to the ischemic tissue are disclosed herein.

System and methods to promote cellular regeneration following ischemia

Anti-angiogenic agents or polypeptides have an amino acid segment substantially similar to domain one of CD2. The polypeptide has a β-sheet formed by two segments. Methods of using such agents and polypeptide are also included.

Anti-angiogenic agent and methods of using such agent

Anti-angiogenic agents or polypeptides have an amino acid segment substantially similar to domain one of CD2. The polypeptide has a &#x3b2;-sheet formed by two segments. Methods of using such agents and polypeptide are also included.

Therapeutic proteins for inducing apoptosis in cells and method for using such proteins are described. The protein, e.g., a chimeric protein, has a host peptide fused to a more stable BH3 domain peptide. The host peptide may be Calbindin D9k, a N-terminal or C-terminal half-domain of Calmodulin, Parvalbimin ('Pa'), an amino acid sequence variant thereof, or a modified variant thereof. The BH3 domain may be Bim, Bid, Bad, Bik, Bmf, Hrk, Puma, or Noxia. Moreover, various conjugates may be attached to the chimeric protein, including a folate and polyethylene glycol.

Calbindin and BH3 domain chimeric proteins and methods for use

Compositions and methods for inhibiting cancer cell metastasis and inflammation are disclosed. The methods generally involve administering to a subject a composition containing an agent that selectively inhibits the binding of p68 RNA helicase to calmodulin (CaM) in the cells.

Method to prevent cancer metastasis and inhibit inflammation by inhibition of p68 interaction with calmodulin

A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.

Targeted contrast agents and methods for targeting contrast agents

A method for stimulating angiogenesis in a tissue of a mammal comprising contacting tissue with a protein substantially similar to pyruvate kinase M2.

Protein to promote blood vessel growth and uses thereof

Anti-angiogenic agents or polypeptides comprising an amino acid segment substantially similar to domain one of CD2 wherein the polypeptide has a &#x3b2;-sheet formed by two segments. Methods of using such agents and polypeptide are also included.

The 30 amino acid peptide GLP-1 has been integrated into the stable host protein human calbindin D9k. The fusion protein binds to GLP-1R. The fusion protein agents can be useful for both diabetes treatment and GLP-1R receptor targeting MR imaging. The fusion protein comprises a first peptide that selectively binds to a site of a target cell and linked to a second peptide, where the fusion protein is more stable than the first peptide alone and may further comprise a detectable label. The first peptide of the fusion protein may be glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-1)(7-36), or glucagon-like peptide-1 (GLP-1) (9-36), or a conservative variant thereof.

Protein agent for diabetes treatment and &#x3b2; cell imaging

Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.

Contrast agents and methods for preparing contrast agents

A method for determining the presence of cancer cells in a tissue sample or cell sample by detecting the presence of phosphorylated p68 RNA helicase in the sample. Further, a method for determining the presence of metastatic cancer cells in a tissue sample or cell sample by detecting the level of phosphorylated P68 RNA helicase in the sample such that a greater level of the phosphorylated protein in the sample as compared to non-metastatic cells is an indication of the metastatic cancer cells in the sample.

Phosphorylated p68 RNA helicase as a marker for cancer and cancer metastasis

The novel dicationic dye N,N'-bis�3,3'-(dimethylamino)propylamine!-3,4,9,10-perylenetetracarboxylic diimide (DAPER) is prepared by reacting 3,4,9,10-perylenetetracarboxylic dianhydride with N,N-dimethylaminopropylamine. The dye DAPER is particularly useful in a rapid, sensitive method for the precipitation, recovery and quantitation of DNA from solutions containing DNA, which method involves the steps of (a) adding the dye DAPER to a solution containing DNA and allowing the resulting mixture to equilibrate; (b) collecting the resulting precipitate; (c) removing weakly bound DAPER from the precipitate; (d) extracting DAPER therefrom by the addition of a solvent therefor; and (e) determining the amount of DNA precipitated by measuring either the absorbance or fluorescence of DAPER in the solvent extract from step (d).

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Marietta, GA, United States of America

Zhi-Ren Liu