Evotec Ag

Renovis, Inc.

Epiodyne, Inc.

Zhi-Liang Wei

John Kincaid

Michael G Kelly

Carl J Kaub

Julio Cesar Medina

Pingyu Ding

Guoxian Wu

Thomas T Nguyen

Xiaodong Wang

Zhan Wang

Jason A Duquette

Satyanarayana Janagani

Yihong Li

Ulhas Bhatt

Alok Nerurkar

Frederick Seidl

Matthew Duncton

Yunfeng Fang

Donogh John Roger O'Mahony

Tien Widjaja

Yeyu Cao

Sumithra Gowlugari

David Lonergan

Martin Holan

John Lee

Heng Cheng

Corinne Sadlowski

Lawrence R McGee

Ravindra B Upasani

David Sperandio

Jianhua He, Legal Representative

Kiran Sahasrabudhe

Carl Kaub

Larry Mcgee

Donogh O'MAHONY

Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

Opioid receptor modulators

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R, R, R, R, R, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Opioid receptor modulators and products and methods related thereto

Compounds are provided according to formula 1: where A, B, W, X', L, R, R, R, and m&#x2032; are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Amide compounds, compositions and uses thereof

Fused heterocyclic compounds are provided according to formula 1a or 1b:  where R, R, and Rare as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof

Fused heterocyclic compounds are provided according to formula 1: where R, R, R, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Bicycloheteroarylamine compounds as ion channel ligands and uses thereof

Growing community of inventors

Foster City, CA, United States of America

Zhi-Liang Wei