International Business Machines Corporation

Centaurus Biopharma Co., Ltd.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Zhi Liang

Bo Yang

Yi Zhao

Ling Shao

Yan Qi Wang

Wei Lu

Wei Xue

Yi Ge

Li Zhu

Ravinder Kumar Sabhikhi

Yuandong Hu

Dengming Xiao

Rong Yu

Quan Hu

Hua Wang

Wei Hu

Yonghua Lin

Kai Zheng

Hai Shan Wu

Yong Peng

Na Zhao

Yongxin Han

Hong Luo

Yinghui Sun

Xijie Liu

Charles Brian Hall

Guo Hui Lin

Zanping Wang

Xiaofeng Zhai

Shixin Wang

Xiao Wei Shen

Yung Hua Lin

The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans. 

Inhibitors of bruton's tyrosine kinase

The invention provides novel substituted 6-arylamino pyridone carboxamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, poly-morph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans. 

6-arylamino pyridone carboxamide as MEK inhibitors

A method and system for processing session initiation protocol messages including receiving a session initiation protocol message by a front end, parsing the session initiation protocol message by the front end, grouping the token types and the token contents in the session initiation protocol message respectively, and setting up corresponding links between the token types and the token contents, wherein the session initiation protocol message, after parsing, is transformed to the session initiation protocol offload engine message with a session initiation protocol offload engine message header part, for storing message level information, a token type part, for storing token type information, wherein it comprises a plurality of fixed-length entries, and a token content part for storing token contents, wherein it comprises a plurality of variable-length entries, and processing the transformed session initiation protocol offload engine message at the server end.

Method and system for processing session initiation protocol messages

A system enabling Transactional Memory with overflow prediction mechanism, comprising: prediction unit for predicting the mode for the next execution of a transaction based on the final status of the previous execution of the transaction; execution unit for executing the transaction in the execution mode predicted by the prediction unit, wherein the execution mode comprises overflow mode and non-overflow made. According to this invention, before a transaction is executed, it is predicted whether or not the transaction will overflow, and therefore, the execution of the transaction which is necessary to determine whether or not an overflow will occur is saved.

System enabling transactional memory and prediction-based transaction execution method

A method and an apparatus are disclosed for improving SIP parse performance. The method comprises the steps of: receiving a text-based SIP message to be sent to a SIP server; according to a SIP message filter table, determining whether the text-based SIP message needs to be transformed to a token-based message; and in the case that the text-based SIP message needs to be transformed to a token-based message, performing the transformation and sending the transformed token-based message to said SIP server, otherwise directly sending the text-based SIP message to said SIP server. According to the present principles, larger SIP message throughput in a SIP server and better utilization of resources of a front end device can be achieved.

Method and apparatus for improving SIP parse performance

The present invention discloses a method and an apparatus for improving SIP parse performance. The method comprising the steps of: receiving a text-based SIP message to be sent to a SIP server; according to a SIP message filter table, determining whether the text-based SIP message needs to be transformed to a token-based message; and in the case that the text-based SIP message needs to be transformed to a token-based message, performing the transformation and sending the transformed token-based message to said SIP server, otherwise directly sending the text-based SIP message to said SIP server. According to the present invention, larger SIP message throughput in a SIP server and better utilization of resources of a front end device can be achieved.

A traffic balancing system, traffic balancing device and traffic balancing method that converts IP packets by switching IP address of the destination host between the dual stack hosts communicating with each other, in order to control traffic balancing in the networks.

Network system, traffic balancing method, network monitoring device and host

A method and apparatus for improving SIP server performance is disclosed. The apparatus comprises an enqueuer for determining whether a request packet entering into the server is a new request or a retransmitted request and its retransmission times and for enqueuing the request packet into different queues based on results of the determining step and a dequeuer for dequeuing the packet in the queues for processing based on a scheduling policy. The apparatus may further include a policy controller for communicating with the server, enqueuer, dequeuer, queues and user, to dynamically and automatically set, or set based on the user's instructions, the scheduling policy, number of different queues, each queue's capacity, scheduling, etc. based on the network and/or server load and/or based on different server applications.

Method and apparatus for improving SIP server performance

The present invention provides a rule set partitioning based packet classification method for Internet. The method comprising: performing Horizontal Cut for the rule set, determining the field for partitioning a rule layer based on a target algorithm and selecting the partition manner of the Horizontal Cut, performing Horizontal Cut according to the selected partition manner of the Horizontal Cut, thereby obtaining more than one rule layers, each rule layer being a Horizontal subset, combining the rule layers to obtain a plurality of Horizontal subsets according to the total number of the pre-designated Horizontal subsets and a predefined principle, wherein the total number of said combined plurality of Horizontal subsets equals to the total number of said pre-designated Horizontal subsets; performing Vertical Cut in each of the Horizontal subsets; then forming a Hash table that can index the Vertical subsets, so that it can be used in a lookup; and realizing rule storage in each Vertical subset respectively according to the target algorithm.

Rule set partitioning based packet classification method for internet

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Beijing, China

Zhi Liang