Western University of Health Sciences

Zhi Jun Wang

Ying Huang

Moses Sing Sum Chow

Jinghua Jeffrey Wang

Ranadheer Ravula

Moses Sing Chow

The invention provides compositions comprising wilforlide A for overcoming drug resistance in cancer therapy, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods and compositions for treating a cancer are disclosed. The method administers to a patient in need thereof a combination of wilforlide A and a chemotherapeutic drug. Wilforlide A and chemotherapeutic drug are administered in a combined amount effective to treat the cancer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug alone.

Use of wilforlide A for overcoming chemotherapy resistance

The invention provides extracts and compositions derived fromfor overcoming drug resistance in cancer therapy. This invention relates to organic solvent extracts ofand their use in cancer treatment, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods of treating a cancer are disclosed. The method administers to a patient in need thereof a combination of (a) an organic solvent extract ofand (b) a chemotherapeutic drug. The organic solvent extract of(a) and chemotherapeutic drug (b) are administered in a combined amount effective to treat the cancer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug (b) alone. Also disclosed are chemotherapeutic compositions comprising a combination of (a) an organic solvent extract ofand (b) a chemotherapeutic drug, wherein (a) and (b) are administered in a combined amount effective to treat the cancer; and a pharmaceutically acceptable carrier.

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Chino Hills, CA, United States of America

Zhi Jun Wang