Zymogenetics, Inc.

Zhi Chen

Wayne R Kindsvogel

Wenfeng Xu

Scott R Presnell

Steven D Hughes

Stacey R Dillon

Anthony W Siadak

Yasmin A Chandrasekher

Margaret Dow Moore

Joyce M Lehner

Pallavur V Sivakumar

Pallavar V Sivakumar

The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.

Anti-IL-20 antibodies and binding partners and methods of using in inflammation

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides polynucleotides, vectors, cells, and methods of production related to a new human cytokine receptor designated as 'Zcytor16.'

Human cytokine receptor

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as 'Zcytor16' and uses thereof.

Method of suppressing or reducing IL-TIF-induced inflammation, or treating associated conditions thereof, using Zcytor16

Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as 'Zcytor16.'

Antibodies to Zcytor 16

Methods for inhibiting IL-TIF-induced proliferation of hematopoietic cells using the cytokine receptor Zcytor16

Polynucleotides encoding human cytokine receptor

Method for detecting cancer using an antibody to Zcytor16

Immunoconjugates of anti-IL-20 antibodies and hybridoma cell lines expressing anti-IL-20 antibodies

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Seattle, WA, United States of America

Zhi Chen