The Johns Hopkins University

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Georgia Tech Research Corporation

Emory University

Florida State University Research Foundation, Inc.

Zhexing Wen

Wei Ping Zheng

Wenwei Huang

Hengli Tang

Ruili Huang

Hongjun Song

Miao Xu

Emily M Lee

Hang Lu

Guo-Li Ming

Menghang Xia

Yichen Cheng

Yi Zhou

Emily Jackson-Holmes

Mesofluidic devices for culturing cell aggregates and methods of using the same are disclosed. An exemplary mesofluidic device comprises at least one fluid inlet, at least one fluid outlet, a plurality of fluid channels, and a plurality of culture chambers. Each culture chamber can comprise at least one chamber inlet and at least one chamber outlet. The at least one chamber inlet can be in fluid communication with the at least one fluid inlet via at least one of the plurality of fluid channels. The at least one chamber outlet can be in fluid communication with the at least one fluid outlet via at least one of the plurality of fluid channels. The mesofluidic device can be configured to contain a cell aggregate in each of the plurality of culture chambers.

Mesofluidic device for culture of cell aggregates

The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

Compounds and methods for treatment and prevention of Flavivirus infection

Growing community of inventors

Atlanta, GA, United States of America

Zhexing Wen