Duke University

Immunolight, LLC

Sandia Corporation

Immunoloight, Llc.

Zhenyuan Zhang

Frederic Avery Bourke, Jr

Michael J Therien

Tuan Vo-Dinh

Joseph H Simmons

Ian Nicholas Stanton

Jennifer Ann Ayres

Joshua T Stecher

Benoit Lauly

Zak Fathi

Molly K Gregas

Jonathan P Scaffidi

Yan Zhang

Stephen John Norton

Venkata Gopal Reddy Chada

Harold Walder

Tina M Nenoff

Dana A Powers

Frederic A Bourke

Jennifer Ayres

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength &#x3bb;, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Non-invasive energy upconversion methods and systems for in-situ photobiomodulation

Non-invasive energy upconversion methods and systems

System for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The system can be used in methods which can be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.

Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength &#x3bb;, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.

A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength &#x3bb;of radiation, to generate a second wavelength &#x3bb;of radiation having a higher energy than the first wavelength &#x3bb;and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength &#x3bb;or the second wavelength &#x3bb;, or with both &#x3bb;and &#x3bb;. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength &#x3bb;, generates the photostimulated reaction.

Up and down conversion systems for production of emitted light from various energy sources

A method of forming stable nanoparticles comprising substantially uniform alloys of metals. A high dose of ionizing radiation is used to generate high concentrations of solvated electrons and optionally radical reducing species that rapidly reduce a mixture of metal ion source species to form alloy nanoparticles. The method can make uniform alloy nanoparticles from normally immiscible metals by overcoming the thermodynamic limitations that would preferentially produce core-shell nanoparticles.

Alloy nanoparticle synthesis using ionizing radiation

Growing community of inventors

Durham, NC, United States of America

Zhenyuan Zhang