Academy of Military Medical Sciences

Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Pr China

The Second Military Medical University

Zhenyuan Miao

Hui Wang

Tao Li

Jie Huang

Jianxin Wang

Yuelin Wu

Jianzhong Yao

Xiong Liu

Chunlin Zhuang

Wannian Zhng

Sen Luo

Chunquan Sheng

Xiaoxue Lu

Deyan Luo

Disclosed are a nicotinic acid or isonicotinic acid compound and a use thereof. The compound is the compound shown in Formula I, or a pharmaceutically acceptable salt, ester or solvate thereof. Efficacy tests demonstrate that the nicotinic acid compound can inhibittoxin endopeptidase activity in vitro, and has a significant protective effect on mice poisoned withtoxin. On this basis, the compound may be used to prepare a drug preventing and/or treatingtoxin exposure and/or poisoning. 

Nicotinic acid or isonicotinic acid compound and use thereof

The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.

Mercaptonicotinic acid compound and preparation method and use thereof

Growing community of inventors

Beijing, China

Zhenyuan Miao