Bontac Bio-engineering (shenzhen) Co., Ltd

Bontac Invitrolife Bio-technology (shenzhen) Co., Ltd

Jiangxi Bonzymes Biotechnology Co., Ltd.

Shenzhen Newdel Biotech Co., Ltd.

Zhenwei Li

Rongzhao Fu

Xinglin Guo

Ke Ding

Jie Wang

Min Wang

Zhengchao Tu

Xiaoyun Lu

Zhang Zhang

Feng Jin

Shuang Xiang

Zhimin Zhang

Xia Tang

Zuqin Wang

Shuihua Zhang

Xun He

The present disclosure relates to Alkynylphenylbenzamide compounds and the applications thereof. The said Alkynylphenylbenzamide compounds have the structure shown in Formula (I). The compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of TRK protein kinase and the proliferation, migration and invasion of various tumor cells. At the same time, it has the characteristics of good pharmacokinetics and low toxicity.

Alkynylphenylbenzamide compounds and applications thereof

An acid phosphatase mutant, and method for preparing nicotinamide riboside by same. The mutant is a protein of the following (a), (b) or (c): (a) a protein, having an amino acid sequence shown in SEQ ID NO: 3; (b) a protein, derived from (a), having catalytic activity higher than an acid phosphatase parent having an amino acid sequence shown in SEQ ID NO: 2, obtained by substituting, deleting or adding several amino acids in the amino acid sequence shown in SEQ ID NO: 3, using nicotinamide mononucleotide as a substrate; (c) a protein, having catalytic activity higher than the acid phosphatase shown in SEQ ID NO: 2, having 90% or more homology with the amino acid sequence of the protein defined by (a) or (b), and using nicotinamide mononucleotide as a substrate. It is used to prepare nicotinamide riboside and the conversion rate can be 99%.

Acid phosphatase mutant, use thereof and method for preparing nicotinamide riboside by same

A nicotinamide riboside composition and preparation method thereof, the icotinamide riboside composition comprises nicotinamide riboside and/or a salt thereof and konjac glucomannan or rebaudioside A. The nicotinamide riboside composition provided by the present invention, used to increase the concentration of NAD in cells, thereby preventing and improving various unhealthy conditions caused by NAD deficiency. is stable in property and easy to store and transport.

Stable nicotinamide riboside composition and preparation method thereof

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Guangdong, China

Zhenwei Li