Tarapeutics Science Inc.

Precedo Pharmaceuticals Co., Ltd

Hefei Gracevo Bio-medicine Co., Ltd

Zhenquan Hu

Jing Liu

Li Wang

Qingsong Liu

Beilei Wang

Ziping Qi

Yi Yang

Cheng Chen

Wenchao Wang

Chen Hu

Aoli Wang

Tao Ren

Shuang Qi

Fengming Zou

Kailin Yu

Wei Wang

Qingwang Liu

Zongru Jiang

Xiaofei Liang

Feiyang Liu

Qiang Wang

Feng Li

Xiaochuan Liu

The present application relates to a compound serving as a selective PI3Kδ kinase inhibitor, comprising the compound shown in formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof, wherein X, R, R, R, R, Rand Rare as defined in the description. The present application also relates to a method for using the kinase inhibitor to inhibit PI3Kδ kinase activity or to treat or prevent diseases or conditions associated with tyrosine kinase activity of PI3Kδ, as well as a use thereof.

Selective PI3Kδ inhibitor and use thereof

The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases. 

Selective C-KIT kinase inhibitor

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Anhui, China

Zhenquan Hu