University of Science and Technology Beijing

Zhong-an Academy of Safety Engineering

Beijing Hanmi Pharmaceutical Co., Ltd.

Zhenlei Li

Xueqiu He

Dazhao Song

Anhu Wang

Shengquan He

Jiawang Liu

Maengsup Kim

Yaping Yang

Nanmeng Song

Lina Zhang

Wenchu Xiao

Menghan Wei

Quan Lou

Chunguang Zhan

Yarong Xue

Hongwei Mu

Donghui Li

Mingyue Gu

An anti-PD-1/anti-VEGF natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof. Provided are a highly stable, heterodimeric form anti-PD-1/anti-VEGF bispecific antibody having natural IgG characteristics and free of mismatched heavy and light chains and preparation method for the antibody. The bispecific antibody is capable of simultaneously binding with two target molecules and provides improved efficacy in treating a complicated disease.

Anti-PD-1/anti-VEGF natural antibody structure like heterodimeric form bispecific antibody and preparation thereof

A method of locating a coal-rock main fracture by an electromagnetic radiation from a precursor of a coal-rock dynamic disaster is provided. At least four groups of three-component electromagnetic sensors are arranged in the underground tunnels, and each group of sensors includes three directive antennas for receiving electromagnetic signals orthogonal to each other. The electromagnetic signals are collected by a monitoring host. The signals are ensured to be received by different sensors synchronously via an atomic clock. The direction of the magnetic field line is determined by performing a vector superposition on strengths of the three-component electromagnetic signals of each group of sensors. The planes of electromagnetic wave propagation perpendicular to the direction of the magnetic field line are determined accordingly. The location of the coal-rock fracture is determined by the intersection point of the planes of electromagnetic wave propagation determined by the multiple groups of sensors.

Method of locating coal-rock main fracture by electromagnetic radiation from precursor of coal-rock dynamic disaster

A multi-system, multi-parameter, integrated, comprehensive early warning method for a coal and rock dynamic disaster includes: obtaining monitoring data of a plurality of monitoring systems for the coal rock dynamic disaster, and extracting multivariate characteristic parameters capable of reflecting precursor information of the coal and rock dynamic disaster in each monitoring system based on the monitoring data; screening out a combination of characteristic parameters with a highest early warning effectiveness in each monitoring system and an optimal critical value of each characteristic parameter based on the multivariate characteristic parameters; calculating a comprehensive early warning index and an early warning effectiveness of each monitoring system; and calculating a multi-system comprehensive early warning result of the coal and rock dynamic disaster based on the comprehensive early warning index and the early warning effectiveness of each monitoring system.

Multi-system, multi-parameter, integrated, comprehensive early warning method and system for coal and rock dynamic disaster

A monitoring and forewarning method for coal-rock dynamic disasters based on an electromagnetic radiation and an earth-sound monitoring includes the following steps: (1) calculating the weighted average value of research parameter P(t) during a time period according to the monitoring data collected by the electromagnetic radiation and the earth-sound monitoring system in real time; (2) calculating D(t), the deviation value of P(t); (3) calculatingas the deviation threshold value, the average value of |D(t)| during period of normal mining of the working surface; (4) calculating D, the number of times that D(t) is greater thanin one day; (5) normalizing Dto obtain the monitoring and forewarning index &#x3b5;; (6) forewarning the hazard state of dynamic disaster of the working surface in real time according to &#x3b5; and forewarning method, determining hazard level.

Monitoring and forewarning method for coal-rock dynamic disasters based on electromagnetic radiation and earth sound

Growing community of inventors

Beijing, China

Zhenlei Li