East China University of Science and Technology

Chinese Academy of Sciences

Other

Yunnan University

Tao Pharmaceutical (Suzhou) Co. Ltd

Zhenjiang Zhao

Honglin Li

Yufang Xu

Jing Liu

Wei Zhou

Hualiang Jiang

Wenlin Song

Shiliang Li

Lili Zhu

Lei Zhang

Jia Tao Li

Jingya Li

Xia Wang

Xuhong Qian

Deheng Sun

Xiaofeng Liu

Zhuo Fan Chen

Ke Xu

Yi Tong

Weilie Xiao

Yuqiong Xu

Liuxin Xu

Hongling Xu

Fang Bai

Mengzhu Xue

Youli Zhang

Lina Quan

Qiao Li

Yanyan Diao

Wanqi Wang

Yingfang Yang

Jianjun Fu

Yinchu Shen

Qian Jiao

The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

Antihypertensive polyol compound and derivative thereof

Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection: 

Applications of novel thiazole derivative in treating virus infection

The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis. The present invention specifically relates to applications of a compound represented by formula I and a pharmaceutical composition containing the compound represented by formula I, in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis: 

Applications of novel thiazole derivative in treating inflammatory bowel diseases

Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease. 

Saponin compound targeting PD-1 and application thereof

The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR. 

Use of pteridinone derivative serving as EGFR inhibitor

A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH. 

Thiazole derivative and applications

The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4. 

Six-membered ring benzo derivatives as DPP-4 inhibitor and use thereof

Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor

Growing community of inventors

Shanghai, China

Zhenjiang Zhao