Gilead Sciences, Inc.

Cv Therapeutics, Inc.

Zhenhai Gao

Luiz Belardinelli

Brent K Blackburn

The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.

Methods of myocardial perfusion imaging

The present invention provides methods of myocardial perfusion imaging and increasing coronary blood flow of a mammal that are accomplished by administering doses of a compound that is a selective partial Areceptor agonist with a short duration of action, in particular regadenoson, useful for, among other indications, myocardial imaging and coronary vasodilation, and determining areas of insufficient blood flow.

Methods of coronary imaging

The present invention provides a method for using the partial adenosine Areceptor agonists having the following structure in myocardiological perfusion imaging.

Myocardial perfusion imaging method

The present invention provides a method for identifying partial adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat arrhythmias in mammals.

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San Jose, CA, United States of America

Zhenhai Gao