Brightgene Bio-Medical Technology Co., Ltd.

Zhengye Wang

Jiandong Yuan

Yangqing Huang

Jianing Gu

Zhanli Sun

Chaohua Liang

Linfeng Miao

The present disclosure involves a composition enriched in compound 61501b, wherein the compound 61501b has a purity of not less than 90% or more. The composition has a significant advantage in preparing a high-purity compound Sp-1. In addition, the present disclosure also provides a preparation method of the composition enriched in compound 61501b. The method adopts a crystallization technique to perform separation and purification, has a simple and convenient operation and good reproducibility, and therefore the compound 61501b in the prepared composition has high purity and quality. Further, the present disclosure also involves a novel crystal form of compound 61501b.

Phosphoramidate compound and preparation method and crystal thereof

Provided is a preparation method of a composition enriched in compound S-1. The method performs isomer separation on a reaction product from the first step, and then performs a two-step chemical synthesis, so as to prepare a composition comprising high-purity compound S-1, wherein the HPLC purity of the single isomer S-1 is 90% or more. Provided is a composition enriched in compound S-1. The composition has an inhibitory effect on tumor cell proliferation in vitro significantly higher than that of NUC-1031 and compound R-1. Also provided are the use of the composition, and a pharmaceutical composition comprising the composition and at least one pharmaceutically acceptable excipient.

Composition enriched in single isomer of NUC-1031 and preparation method and use thereof

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Suzhou, China

Zhengye Wang