Cedars-sinai Medical Center

Zhengwei Zhou

Debiao Li

Zhaoyang Fan

Anthony Christodoulou

Yibin Xie

Christopher Nguyen

Jaime Shaw

Zixin Deng

Nan Wang

Sen Ma

Gadi Pelled

Dan Gazit

Zulma Gazit

A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.

Low-rank tensor imaging for quantitative MRI

In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.

Non-invasive pH-dependent imaging using quantitative chemical exchange saturation transfer (qCEST)

A method of determining an exchange rate between a solute material and a solvent material in chemical exchange with each other in a sample comprises performing a plurality of CEST scans on the sample to determine a reference data signal and a label data signal; simulating a plurality of CEST scans on the sample to obtain a reference dictionary signal and a plurality of label dictionary signals, each label dictionary signal corresponding to a candidate exchange rate; correcting the reference dictionary signal and each label dictionary signal for a magnetization transfer effect; determining a final data signal based on the reference data signal and the label data signal; determining a plurality of final dictionary signals based on the reference dictionary signal and the plurality of label dictionary signals; and determining the exchange rate by matching the final data signal to one of the plurality of final dictionary signals.

Methods and systems for chemical exchange saturation transfer signal matching

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Los Angeles, CA, United States of America

Zhengwei Zhou