The United States of America, as Represented by the Secretary, Department of Health and Human Services

The United States of America as Represented by the Secretary of

The United States of America as Represented by the Department of Health

Lixte Biotechnology, Inc.

Asclea Corporation

Microvizual, Inc.

Zhengping Zhuang

Lance A Liotta

Robert F Bonner

Michael E Buck

Rhonda Ann Weiss

Irina A Lubensky

Francis S Collins

John S Kovach

Michael R Emmert-Buck

William G Stetler-Stevenson

Mark Roth

Allen M Spiegel

Enhong Jiang

Anthony Cappadona

Young Wan Moon

Sze Chun Winson Ho

Michael R Buck

Herui Wang

Rongze Lu

Jing Cui

Stephen J Marx

A Lee Burns

Sunita K Agarwal

Larisa V Debelenko

Pachiappan Manickam

Siradanahalli Guru

Settara Chandrasekharappa

Jie Lu

Russell Lonser

Chunzhang Yang

Disclosed is plate or film for collecting and analyzing a sample. The plate or film includes a surface and a plurality of slices from the sample immobilized on the surface. Further, the plurality of slices are cut from the sample with equal thickness, and the plurality of slices are placed on the surface of the plate or film following their cutting order.

Automatic system and method for tissue sectioning, staining, and scanning

The present invention provides a method of treating a subject afflicted with cancer comprising administering to the subject an effective amount of a PP2A inhibitor.

Oxabicycloheptanes for modulation of immune response

A pharmaceutical composition containing any one or more of 4&#x2033;-O-isolvalerylspiramycin I, II and III counters tumorigenesis and reduces or prevents metastasis by inhibiting selenoprotein H to trigger genomic instability and cell-cycle arrest in cancer cells.

Use of isovalerylspiramycins as anti-cancer agents to inhibit metastasis

The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.

[object Object]

A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.

Isolation of cellular material under microscopic visualization

A method of direct extraction of cellular material from a tissue sample which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extracted zone(s) of cells is subjected to analysis. The overall process of identifying, extracting, transporting, and analyzing the extracted zones(s) of cells can be fully automated.

Isolation of cellular material under microscopic visualization using an

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Bethesda, MD, United States of America

Zhengping Zhuang