Other

Zhu, Zhenglun

Gao, Hong

Zhenglun Zhu

Hong Gao

Hong P Gao

A method of treating an inflammatory disorder in a subject, comprising administering to a subject in need thereof a nucleic acid molecule for inhibiting the expression of Hom-1.

Treatment and diagnosis of inflammatory disorders

A method of treating an inflammatory disorder in a subject, comprising administering to the subject in need thereof a nucleic acid molecule for inhibiting the expression of Hom-1. Specifically, the nucleic acid molecule is an RNAi agent or an antisense morpholino oligonucleotide. Further disclosed is a method of selecting a therapeutic for an inflammatory disorder in a subject, or monitoring the efficacy of a therapeutic for an inflammatory disorder in a subject, comprising detecting the expression level of Hom-1 in an inflamed tissue sample obtained from the subject.

Disclosed are composition and methods for treating immune disorders. Also disclosed are diagnosis methods and prognosis methods.

Treatment and diagnosis of immune disorders

The invention relates to human homeobox transcription factor VentX and its regulation of differentiation and maturation of human dendritic cells, and related therapeutic and diagnostic compositions and methods of use.

Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells

The invention generally relates to human biology discoveries and therapeutic and diagnostic compositions and methods based thereon. More particularly, the invention relates to human homeobox gene VentX and its control of macrophage terminal differentiation and activation, and related therapeutic and diagnostic compositions and methods of use, in particular in connection with inflammatory diseases.

Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof

Described is a method of expanding hematopoietic stem or progenitor cells. The invention further includes a method of treating primary or secondary bone marrow failure syndrome.

Method of expanding hematopoietic stem cells

A method of expanding hematopoietic stem cells. Also disclosed is a method of diagnosing primary or secondary bone marrow failure syndrome. The invention further includes a method of treating primary or secondary bone marrow failure syndrome.

Expanding hematopoietic stem cells

Disclosed are composition and methods for treating development-related disorders. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods.

Cancer prognosis by determining phosphorylation of a Xom polypeptide

Disclosed are methods for treating immune disorders using inhibitors of Hom-1. The inhibitors include an RNAi agent containing the sequence of SEQ ID NO: 6.

Treatment of immune disorders with Hom-1 inhibitors

Disclosed are compositions comprising Hom polypeptide (also known as Xom, Ventx2) and methods for treating cellular proliferative disorders comprising. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods.

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Allston, MA, United States of America

Zhenglun Zhu