Eastman-kodak Company

3m Innovative Properties Company

Zheng Zhi Wu

Jared B Mooberry

David T Southby

Jerrold N Poslusny

David Hoke

James J Seifert

Elizabeth E Johnson

Wojciech K Slusarek

Frank D Coms

James P DiZio

Peter R Johnson

Nayna Govind

Amy Preszler Prince

Lawrence G Anderson

Xiqiang K Yang

Kevin P Dockery

Steven M Bonser

Chang-Kyu Kim

James Patrick DiZio

Amy Preszier Prince

A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.

Transdermal adhesive compositions, devices, and methods

Transdermal adhesive compositions, devices and methods

A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to reduce chemical degradation of such steroids.

Process for making chemically stable C-17/21 OH 20-ketosteroid aerosol products

C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability

The invention provides a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a coupler based on a 1-aryl-3-arylpyrazol-5-one ring and represented by formula I:

Photographic element containing a stable aryloxypyrazolone coupler and process employing the same

The invention provides a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith an 1-arylpyrazol-5-one coupler bearing a 4-aryloxy coupling-off group containing a group capable of releasing a photographically useful group (PUG) wherein: (1) the 1-arylpyrazol-5-one ring contains a 3-aryl substituent which in turn contains substituents for which the sum of the Hammett's .sigma. constant values is at least 0, provide that two or more such substituents may join to form one or more additional rings; and (2) the 4-aryloxy coupling-off group:

Photographic element containing pyrazolone PUG releasing coupler and

Disclosed is a photographic element containing a light sensitive silver halide emulsion layer having associated therewith a coupler represented by Formula I: ##STR1## wherein COUP is a coupler parent group capable of reacting with an oxidized developer to form a first dye and is bonded at a coupling position to the group ##STR2## wherein X is a or NSO.sub.2 R; R is an alkyl or aryl group; and DYE is a releasable second dye that is after release the same color as the first dye and is linked to OC.dbd.X by a moiety of the DYE having Formula (IA): ##STR3## wherein R.sup.2 is a substituent; provided there is contained in the coupler of Formula I at least one group of Formula IB:

Photographic element containing high dye-yield couplers

A photographic element comprises a light-sensitive silver halide emulsion layer having associated therewith a coupler based on a 1-aryl-2-pyrazolin-5-one ring and represented by formula I: ##STR1## wherein: Ar.sup.1 and Ar.sup.2 are each independently aryl groups comprising a carboaromatic or heteroaromatic ring; X, Y, and Z are bonded to a carbon atom alpha to the 3-position and are independently selected from the group consisting of hydrogen and substituent groups such that the sum of the Taft .sigma.* values for X, Y, and Z is at least 1.5; R represents n independently selected substituent groups bonded to the Ar.sup.2 ring, provided that the sum of the appropriate Hammett .sigma. constants for all R substituent groups is at least 0.3, and provided further that two of X, Y, and Z may join to form a ring; and n is 0 to 5; provided that R may not be a nitro group ortho to the oxygen atom bonding Ar.sup.2 to the 1-aryl-2-pyrazolin-5-one ring.

Photographic element containing a stable aryloxypyrazolone coupler and

The invention provides a photographic element comprising a substrate bearing a photographic silver halide emulsion layer having associated therewith a high dye-yield coupler having the formula: ##STR1## wherein: COUP is a photographic coupler residue capable of coupling with oxidized color developer to form a first dye;

Photographic element containing a high dye-yield coupler with methine

The invention provides a photographic element comprising a support bearing a photographic silver halide emulsion layer having associated therewith a high dye-yield coupler having the formula:

Photographic element containing high dye-yield couplers having improved

Growing community of inventors

Woodbury, MN, United States of America

Zheng Zhi Wu