Yangtze River Pharmaceutical Group Co., Ltd.

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Shanghai Bst Electrical Appliance Manufacturing Co., Ltd.

Institute of Basic Medical Sciences, Academy of Military Medical Sciences

Shanxi Yabao Pharmaceutical Group Corp.

Zheng Yang

Wei Feng

Zhiyuan Zhang

Fusheng Zhou

Weiwei Wang

Xiangyu He

Zhongqin Wang

Sida Shen

Wuxian Ren

Xiaojing Ni

Guozhang Jin

Jijun Chen

Ming Fan

Disclosed is a 2-morpholin-4,6-disubstituted pyrimidine derivative as shown in formula (1) below, and a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof, and a pharmaceutical composition thereof and a use thereof, wherein the definition of each group is as shown in the description. The compound has a PI3K kinase inhibition activity, and has a relatively high inhibitive ability and a low cytotoxicity against PIK3CA mutant breast cancer cell strains T47D and MCF-7.

2-morpholin-4,6-disubstituted pyrimidine derivative, and preparation method and pharmaceutical use thereof

The present invention relates to a magnetic latching relay which can avoid influences of erection stress on internal structure parameters thereof. The magnetic latching relay includes a yoke assembly, a magnetic steel assembly, a contact system having movable and immovable contact spring assemblies and a pusher pad, and a shell having a bottom case and an upper cover. Back contact springs of the movable contact spring assembly are arc-shaped and stacked on one side of each movable contact spring of the movable contact spring assembly. The bottom case has clip-shaped bosses which are formed outside two side walls of the bottom case to fasten extension ends of the movable and the immovable contact springs and supported with bolts to clamp the springs extending out of clip-shaped openings of the bosses.

Magetic latching relay

Growing community of inventors

Shanghai, China

Zheng Yang