USA As Represented by Secretary of the Navy

Zheng Wang

David A Stenger

Baochuan Lin

Joel M Schnur

Brandy J White

Anthony P Malanoski

Martin H Moore

Gary J Vora

Clark J Tibbetts

Robb K Rowley

Elizabeth A Walter

Dzung C Thach

Jennifer Johnson

Donald Seto

Russell P Kruzelock

Eric H Hanson

Brian K Agan

Gaurav J Vora

The application of melanin to fabric improves resistance to chemical pass-through, with possible application in protective garments, shelters, and filtration materials.

Melanin-based chemical protective materials

The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.

Re-sequencing pathogen microarray

A computer-implemented method as follows. Providing a list of target sequences associated with one or more organisms. Providing a list of candidate prototype sequences suspected of hybridizing to one or more of the target sequences. Generating a collection of probes corresponding to each candidate prototype sequence, each collection of probes having a set of probes for every subsequence. The sets consist of the corresponding subsequence and every variation of the corresponding subsequence formed by varying a center nucleotide of the corresponding subsequence. Generating a set of fragments corresponding to each target sequence. Calculating the binding free energy of each fragment with a perfect complimentary sequence of the fragment. Determining which extended fragments are perfect matches to any of the probes. Assembling a base call sequence corresponding to each candidate prototype sequence.

Design and selection of genetic targets for sequence resolved organism detection and identification

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Burke, VA, United States of America

Zheng Wang