Shanghai Jiaotong University

Nippon Chemical Industrial Co., Ltd.

Sph No. 1 Biochemical & Pharmaceutical Co., Ltd.

Zhenfeng Zhang

Wanbin Zhang

Jing Li

Liang Wu

Lu Zhang

Feng Gao

Ken Tamura

Tsuneo Imamoto

Wei Yu

Yujia Fu

Xiaohong Huo

Qiupeng Hu

Jianzhong Chen

Yuanlin Wang

Qianjia Yuan

Ximing Jiang

Mo Wang

Yaohua Zhang

A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.

Low-temperature continuous-flow preparation method of bedaquiline

A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3) 

Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein

A method for preparing chiral &#x3b3;-secondary amino alcohol includes: adding into a solvent an acid addition salt of &#x3b2;-secondary amino ketone represented by general formula (1), an alkali, a metal salt additive and a diphosphine-rhodium complex, so as to carry out a reaction in a hydrogen atmosphere and obtain a chiral &#x3b3;-secondary amino alcohol compound represented by general formula (2). In general formula (2), Ar represents an aryl group with or without substituent group(s), R represents an alkyl group or an aralkyl group, and HY represents an acid. The synthesis scheme has a simple process, the metal salt additive remarkably improves the effect of a rhodium-catalyzed asymmetric hydrogenation technology, and accordingly, the reaction yield and the optical purity of a product are improved, the production process is simplified, production costs are reduced, and the synthesis scheme is highly suitable for mass industrial production. 

Method for preparing chiral gamma-secondary amino alcohol

Provided are a novel 1,2-bis(dialkylphosphino)-4,5-(methylenedioxy)benzene derivative that forms a metal complex having particularly high asymmetry induction capacity and catalytic activity on &#x3b2;-dehydroamino acids, a method for manufacturing the same, a metal complex having this 1,2-bis(dialkylphosphino)-4,5-(methylenedioxy)benzene derivative as a ligand, and an asymmetric hydrogenation method using this metal complex. A 1,2-bis(dialkylphosphino)-4,5-(methylenedioxy)benzene derivative represented by general formula (1). (In the formula, Rand Rrepresent an alkyl group having 1-10 carbon atoms, and Rand Rhave different numbers of carbon atoms.) 

Device and method for evaluating organic material for organic solar cell

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Shanghai, China

Zhenfeng Zhang