Chinese Academy of Sciences

Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Wuhan China Star Optoelectronics Semiconductor Display Technology Co., Ltd.

Sap Se

Shanghai Institute of Pharmaceutical Industry

Other

Huawei Technologies Co., Limited

Emc IP Holding Company LLC

Shanghai United Imaging Healthcare Co., Ltd.

Fudan University

Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

China State Institute of Pharmaceutical Industry

Jiangsu Sixin Scientific-technological Application Research Institute Co., Ltd.

Zhen Zhang

Yunfei Li

Jian Ge

Yijin Wang

Xin Xu

Jian Ye

Liming Zhang

Xiaoer Xia

Xiaojuan Zhang

Hui Li

Lei Liu

Ying Liu

Xia Yu

Jia Chen

Quanhai Liu

Li Cai

Li Chen

Dongsheng Li

Fang Chen

Chaoyang Liu

Minyu Liu

Xuejun Wu

Xiaoling Huang

Qingyun Jiang

Lin Xiao

Yifang Deng

Renhai Chen

Junfei Chen

Fengying Guo

Linli Zhang

Jiwen Feng

Wei Zhang

Qiang Li

Weikang Tao

Liang Liu

Fan Yang

Lianshan Zhang

Ling L Zhang

Lei Yu

Guan Zhong Wang

Jun Zhao

Yifeng Wang

Qiang Liu

Tao Wei

Jingjie Zhou

Guoping Wang

Peiyu Zhuang

Hao Yu

Yayuan Fu

Dongbing Cui

Jing Su

Yong Xi

Tao Cheng

Jinyao Chen

Yifang Wang

Tian Cao

Guobin Ren

Dabin Feng

Jiajian Liu

Xiaobo Zhou

Yige Zhang

Ling Zhang

Fei Dong

Zheng Xi

Minjie Zhang

Xuesi Chen

Yan Qin

Kang Sun

Jiamiao Wang

Rujie Zhu

Tao Feng

Haiyan Sun

Zhiru Xu

Chungang Li

Zhenpeng Yu

Gouping Wang

Mianli Pan

Jinqian Song

Shenrong Tang

Guijun Ma

Dongsheng Nie

Liling Jin

Panqi Luo

Xiangduan Tan

Chunling Zeng

Zhiyang Lv

Yumei Gao

Jun Ren

Shiping Bo

Desheng Lv

Sijia Lu

Xinwen Wang

Wei Ren

Xiangkai Peng

Kangkang Liu

Jingfeng Xiang

Joshua D Hutt

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

The present disclosure may disclose methods and systems for treating an object. The method may include imaging an object fixed on a positioning device using an imaging device. The method may include obtaining a plan image of the object. The method may include generating information of a region of interest (ROI) of the object based on the plan image of the object. The method may include generating a treatment plan based on the information of the ROI. The treatment plan may include a plan isocenter on the plan image. The method may further include treating a target portion of the object based on the treatment plan using a treatment device. The object may be fixed on the positioning device from a moment that the object is started to fixed on the positioning device to an end of the treatment of the target portion.

Methods and systems for treating an object

Methods, systems, and computer-readable storage media for receiving, from a first entity, a first call, the call being received by a middleware client of a second entity, storing a set of headers associated with a workflow in a request context holder of the middleware client, and determining that a second call is to be executed from the middleware client of the second entity for the workflow, and in response: reading, by a client of the middleware client, the set of headers associated with the workflow, including the headers in a request of the second call, determining an endpoint for the second call, and transmitting the second call for receipt at the endpoint.

Middleware for communication between microservices and monolithic application

Methods, systems, and computer-readable storage media for receiving metric data of a cloud system periodically; transforming the metric data of each type into a byte array using mapping tables, wherein the byte array is an encoded format of the metric data, where each field of the metric data is encoded as a field ID and a field type ID that are short integer variables; merging and storing the byte arrays of multiple metric data into a binary file, wherein the binary file comprises multiple blocks with each block comprising multiple byte arrays; generating indexes for common fields of different metric data in the binary file; receiving a retrieval request requesting metric records including a common field of a particular value; determining storage locations of one or more metric records satisfying the retrieval request; and obtaining the one or more metric records from the binary file using the corresponding storage locations.

Metrics data storage and access

Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.

JAK kinase inhibitor, preparation method for same, and applications thereof in field of medicine

A new image formation model for descattering different from the previous works based on atmospheric scattering model is established. It can provide a corresponding physical explanation for each scattering environment, illustrate a relationship between a light source position and scattering conditions and solve the problem of scattering removal under non-uniform illumination. Firstly, a dark angle of a camera is removed by an integrating sphere; then, a pure scattering part is found by an improved dark channel-like prior method; and finally, a zenith angle, an azimuth angle, an extinction coefficient and other related physical quantities are calculated according to the light attenuation and backscattering distribution of a scattering medium to eliminate the backscattering and light attenuation. Theoretically, the model can be used in any uniform scattering medium, such as underwater and fog environments, and works well in high-density media.

Image restoration method based on physical scattering model

The present invention provides a polyethylene glycol derivative comprising a repeat unit having the structure of Formula (I) and a terminal group having the structure of Formula (II). The polyethylene glycol derivative provided by the present invention has good biocompatibility, due to the repeat unit having the structure of Formula (I); and can react with various groups such as amino, (acyl)hydrazino, and aminooxy with a fast reaction rate under mild reaction conditions, due to the o-phthalaldehyde terminal group having the structure of Formula (II). The polyethylene glycol derivative provided by the present invention is mixed with polyethylene glycol having an amino-containing terminal group in an aqueous medium, to rapidly form a chemically cross-linked hydrogel material. The hydrogel material has mild preparation conditions, fast gel-forming speed, high mechanical strength, and good stability. This polyethylene glycol hydrogel can be applied as drug sustained-release carrier, tissue engineering scaffold, etc. in the field of biomedical materials.

Polyethylene glycol derivative, preparation method thereof, and polyethylene glycol hydrogel capable of producing a rapid crosslinking reaction

A touch substrate and a display panel are provided by this disclosure. The touch substrate includes a plurality of touch units, each touch unit has a first electrode and a second electrode. The first electrode includes a first trunk electrode and a plurality of first branch electrodes. The first trunk electrode is parallel to a first direction. The first branch electrodes are disposed on two sides of the first trunk electrode. The first branch electrodes extend outwardly with the first trunk electrode as a center to form a radial structure. The second electrode includes a second trunk electrode and a plurality of second branch electrodes. The second trunk electrode is parallel to a second direction. The second branch electrodes are disposed on two sides of the second trunk electrode. The first branch electrodes and the second branch electrodes are alternately disposed to form an occlusal structure.

Touch substrate and display panel

The present application discloses a touch panel and a mobile terminal; each of first electrode groups of a touch layer of the touch panel includes a first main electrode group and first branch electrodes, and each of second electrode groups includes a second main electrode group and a plurality of second branch electrodes, while the first branch electrodes are provided with first openings and the second branch electrodes are provided with second openings, so as to reduce a total facing area of both the first electrode groups and the second electrode groups and a cathode layer, thereby improving reliability of an operation of the touch panel.

Touch panel and mobile terminal

A touch substrate and a display panel are provided. The touch substrate includes a plurality of touch units. Each of the touch units includes a first electrode and a second electrode disposed electrically insulated from each other. The first electrode includes a first main branch electrode extending along a first direction, and at least one first branch pattern and at least one third branch pattern respectively disposed on two sides of the first main branch electrode. The second electrode includes a second main branch electrode extending along a second direction perpendicular to the first direction, and at least one second branch pattern and at least one fourth branch pattern respectively disposed on two sides of the second main branch electrode.

A method for separating oil-water two-phase NMR signals by using dynamic nuclear polarization comprising: using a combination of a non-selective free radical and a selective relaxation reagent to selectively enhance an NMR signal of an oil phase or a water phase, the relaxation reagent being capable of selectively suppressing dynamic polarization enhancement of the water phase or oil phase, thus achieving the polarization enhancement of a single fluid phase in the mixed fluid phases and realizing separation of the two-phase signals; or using a selective free radical to selectively enhance the NMR signal of the oil phase or the water phase, thus achieving the polarization enhancement of a single fluid phase in the mixed fluid phases and realizing separation of the oil-water two-phase NMR signals. The method is simple and easy to operate, has a short test time, and can efficiently separate NMR signals of oil and water phases.

Method for separating oil-water two-phase NMR signals by using dynamic nuclear polarization

Provided is a method for identifying balanced translocation breakpoints and a carrying state for balanced translocations in embryos, comprising the following steps: amplifying and sequencing a sample; comparing the sequence which is obtained by means of sequencing with a reference genome and analyzing copy numbers; accurately determining the position of a translocation breakpoint; detecting single nucleotide polymorphisms (SNPs) around the breakpoint and genotyping the SNPs; analyzing an embryonic haplotype, and comprehensively determining a normal chromosome and a translocation chromosome haplotype; determining the embryonic carrying state and, according to the haplotype, selecting an embryo which does not carry a balanced translocation.

Method for identifying balanced translocation break points and carrying state for balanced translocations in embryos

An engine valve actuating apparatus includes a housing that contains an activation piston bore and an actuation piston bore. The activation piston is disposed in the activation piston bore and configured to actuate an engine valve. The actuation piston includes at least one side surface that is in sliding contact with the inner surface of the actuation piston bore so that the actuation piston can slide within the actuation piston bore. The actuation piston also has a guide mechanism, which guides the first and second links to move in a plane between the first position and the second position. At least a part of the guide mechanism is below at least a part of the at least one side surface of the actuation piston.

Engine valve actuating apparatus

A method for measuring oil-water distribution using DNP-MRI, comprising adding a free radical for DNP enhanced NMR signal of a water phase or an oil phase in a sample containing oil and water; performing an MRI experiment on the sample, and collecting an MRI image of the sample without DNP enhancement; applying microwave excitation for DNP-MRI experiment under the same MRI experiment condition as step 2, and collecting an MRI image of the sample after DNP enhancement; and comparing the MRI image after DNP enhancement with the MRI image without DNP enhancement. In the MRI image with DNP enhancement, an area with enhanced MRI signal intensity is a selectively enhanced fluid phase distribution area, and an area without obviously changed MRI signal intensity is a non-selectively enhanced fluid phase distribution area. The method is simple, convenient to operate, short in measurement time, and high in measurement efficiency.

Method for measuring oil-water distribution using dynamic nuclear polarization for magnetic resonance imaging (DNP-MRI)

Disclosed are a class of &#x3bc;-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The &#x3bc;-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

&#x3bc;-opioid receptor agonist and preparation method therefor and use thereof in field of medicine

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Shanghai, China

Zhen Zhang