Zhejiang Hisun Pharmaceutical Co., Ltd.

Zhen Yu

Hua Bai

Na Li

Jun Huang

Linghui Zheng

Meihong Li

Haibin Wang

Jidong Wang

Anliang Chen

Aiwen Deng

Jiatan Lin

The invention provides a construction method of spinosad heterologous expression strain, a spinosad heterologous expression strain obtained by the method and use thereof in preparing spinosad. The method utilizes a plurality of homologous recombination to replace the erythromycin synthetic gene cluster ofwith the spinosad synthetic gene cluster and the rhamnose synthetic gene cluster, such that theproduces spinosad.

Spinosad heterologous expression strain and construction method thereof and use

The present invention relates to a recombinant microorganism expressing avermectin or analogs thereof and construction method thereof, and also relates to a method of producing avermectin or analogs thereof using the recombinant microorganism, and avermectin or analogs thereof obtained using the method. In addition, the present invention further relates to uses of the avermectin or analogs thereof as insecticides. Using the recombinant microorganism of the present invention to produce avermectin or analogs thereof has numerous advantages, for example comprising at least one of the following: good stability, high yield, simple process, environmentally friendly, and greatly saving of production costs.

Recombinant microorganism expressing avermectin analogue and use thereof

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Zhejiang, China

Zhen Yu