Xtl Biopharmaceuticals Ltd.

Other

The UAB Research Foundation (The University of Alabama at Birmingham)

Vivoquest, Inc.

University of California

Peking University

Kaiyew Investment Corp.

Jenisa Biotechnology Corp.

Fuzians Biomedicals, Inc.

Zhen Yang

Reza Fathi

Qiang Zhu

Yixin Liu

Anthony Sandrasagra

Yun Liao

Hyun-Joon Cho

Kenneth Nawoschik

Ming Luo

C Richard Wobbe

Youhong Hu

Bin Xu

Jie Wu

Hang Shi

Yew-Min Tzeng

Chi-Tai Yeh

Guoxin Wang

Shuo Lin

Guolin Li

Angela Lam

Jie Cao

Chuang-Chuang Li

Wu Ruoqiu

Lisha Wang

Hongchang Yu

Tuo-Ping Luo

Chaodong Wang

Zhongqing Zai

The present invention provides a method for preparing antrocin of pharmaceutically acceptable salts thereof via a series of gold-catalyzed cyclization to construct the (6-6-5) tricyclic core frame. The present invention also provides a use of a composition in preparing drugs for suppressing growth of non-small cell lung cancer cells, wherein the composition comprises an effective amount of antrocin or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier.

Method for chemical synthesis of antrocin and use thereof for suppressing non-small cell lung cancer

Novel 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives that are effective for use in treating viral infections are described. Also described are pharmaceutical compositions comprising the 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives and methods for using the compounds or compositions.

Compounds useful as antiviral agents, compositions, and methods of use

Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using the compounds and their compositions in treating or preventing viral infections.

Treating and preventing viral infections

Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.

Pyrazole compounds

Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein.  Compositions including the compounds having the formula I-A in which the variables have the definitions described herein, and methods of using the compositions for the treatment of certain diseases mediated by the up-regulation of Smo are also disclosed. 

Cyclohexylamines, phenylamines and uses thereof

The present invention relates to 4-thio substituted quinoline and naphthyridine derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 4-thio substituted quinoline or naphthyridine derivative.

4-thio substituted quinoline and naphthyridine compounds

The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative.

3,4-disubstituted coumarin and quinolone compounds

The present invention relates to benzofuran derivatives for use in antiviral compositions. More specifically, the present invention relates to compositions and methods for the treatment of hepatitis C virus by administering the benzofuran derivatives in a therapeutically effective amount.

Benzofuran compounds

4-ethynyl pyrazole derivative compounds and methods for treatment of HCV

4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by adiministering 4-thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers.

4-thio coumarins

Benzo[b]furan dimers and processes for their preparation are provided. The invention provides a synthetic process for the preparation of benzo[b]furan dimer using mild reaction conditions, which provides a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of benzo[b]furan dimers for biological screening.

Benzo[b]furan dimers

4-thio substituted coumarin derivatives and coumarin dimers are provided, as well as processes for their preparation. A synthetic process for the preparation of 4-thio substituted coumarin derivatives is provided using mild reaction conditions, which maintains a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of 4-thio substituted coumarin derivatives for biological screening.

A thermostable polycrystalline diamond body is produced by pre-treating the diamond crystals with molten base or salt, mixing the pre-treated diamond crystals with silicon powder or a blend of silicon and one or more substances, subjecting the mixture to a combination of high-pressure and high-temperature and maintaining the pressure and temperature for a period of time. The thermostable polycrystalline diamond body is characterized in having diamond crystals uniformly distributed in the body. The diamond crystals are covered by .beta.-silicon carbide and that the diamond crystals together with .beta.-silicon carbide form an uninterrupted framework throughout the entire body, the interstices of which are filled with elemental silicon or silicon-containing refractory phases. A polygonal graphite mold having walls of equal thickness useful in the production of said thermostable polycrystalline diamond body is also provided.

Thermostable polycrystalline diamond body, method and mold for producing

Growing community of inventors

Ridgewood, NJ, United States of America

Zhen Yang