Rhodia Operations

Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Centre National De La Recherche Scientifique

Suzhou Suncediabiopharmaeuticals Co., Ltd.

Zhen Yan

Xun Liu

Philippe Marion

Weikang Tao

Piaoyang Sun

Jie Li

Sergio Mastroianni

Lianshan Zhang

Stéphane Streiff

Armin Liebens

Yan Fang

Armin T Liebens

Pingping Wang

Javier Diaz-Maroto Carpintero

Shan Wu

Floryan Decampo

Marc Pera Titus

Mohamad Ousmane

Marc Pera-Titus

Jingjing Fang

Jianjian Yang

Xiaodan Yan

Lin Fang

Bright Kusema

The present invention relates to a method of synthesizing at least one organic acid comprising oxidizing glycolaldehyde with nitric acid in the presence of a solvent. Advantageously, it is an industrially applicable process, which prepares organic acid, notably glycolic acid and/or glyoxylic acid in a high yield based on bio-based feedstocks.

Method of oxidizing glycolaldehyde using nitric acid

The present invention provides a PD-L1 antibody pharmaceutical composition and use thereof. In particular, the present invention provides a pharmaceutical composition comprising the PD-L1 antibody or an antigen-binding fragment thereof in a succinate buffer. In addition, the pharmaceutical composition may also contain a sugar and a nonionic surfactant.

PD-L1 antibody pharmaceutical composition and use thereof

A pharmaceutical composition containing an SOST antibody or an antigen-binding fragment thereof in an acetic acid-sodium acetate buffer solution is described. In addition, the pharmaceutical composition can also contain sugar, a nonionic surfactant or other excipients. After being stored for several months, the pharmaceutical composition exhibits good antibody stability.

SOST antibody pharmaceutical composition and uses thereof

The present invention concerns a process for forming a primary or a secondary amine via amination reaction comprising: reacting an alcohol with an amine in the presence of a zeolite comprising a transition metal chosen in the group consisting of Group 8 to 12 elements of the Periodic Table and any combination thereof.

Production of amines utilizing zeolite catalysts

A stable anti-PD-1 antibody pharmaceutical preparation and an application thereof in a medicine. The anti-PD-1 antibody pharmaceutical preparation comprises an anti-PD-1 antibody, a buffer, and can further comprise at least one type of stabilizer, and optionally can further comprise a surfactant. The anti-PD-1 antibody pharmaceutical preparation of the present invention can effectively suppress antibody aggregation and deamidation, thereby preventing degradation of an antibody product, resulting in a stable injectable pharmaceutical preparation.

Stable anti-PD-1 antibody pharmaceutical preparation and application thereof in medicine

Providing a process for forming an amine, such as a primary, a secondary or a tertiary amine, via the direct amination of an alcohol using a catalyst comprising at least a palladium compound on a support comprising cerium oxide.

Process for forming amine by direct amination reaction

Disclosed is a process for preparing a primary, a secondary or a tertiary amine via the direct amination of an alcohol in the presence of a catalyst. The catalyst is composed of palladium or a palladium compound and a cerium oxide supporter.

Process for forming a primary, a secondary or a tertiary amine via a direct amination reaction

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Shanghai, China

Zhen Yan