Boe Technology Group Co., Ltd.

Hefei Boe Optoelectronics Technology Co., Ltd.

Jenkem Technologyco., Ltd.. (tianjin)

Jenkem Technology Co., Ltd. (beijing)

Beijing Boe Display Technology Co., Ltd.

Jenkem Technology Co., Ltd.

Zhen Wei

Xuan Zhao

Meina Lin

Min Xu

Chengda Zhu

Weiwei Sun

Shibo Guo

Feng Li

Qiang Zhang

Yang Wang

Hui Zhu

Jinliang Wang

Zewang Feng

Wen Li

Guodong Li

Kiyoung Kwon

Jianyang Yu

Yanping Song

Qiong Zhao

Xiuxing Fu

Xing Ge

Jian Sheng

Yongbo Gong

Yuanyi Cai

Lixing Zhang

Mingming Shen

Qingsheng Li

Kun Zheng

Chenchen Jiang

Being used for drug modification, the multi-arm single molecular weight polyethylene glycol active derivative provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the multi-arm single molecular weight polyethylene glycol active derivative provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.

Multi-arm single molecular weight polyethylene glycol active derivative and application thereof

A PEG linker as represented by formula (I), wherein n and m are respectively an integer from 1 to 7, providing the PEG linker with 1 to 49 linking sites. A ligand drug conjugate as represented by formula (II). The conjugate uses the PEG linker to increase a drug loading capacity and drug loading diversity, thereby improving pharmaceutical efficacy.Y1-PEG1-{R-PEG2-{Y4}}&#x2003;&#x2003;(I)TM-{R-PEG1-{R-PEG2-{R-A'-drug}}}&#x2003;&#x2003;(II)

Peg linker and ligand drug conjugate

Being used for drug modification, the multi-arm single molecular weight polyethylene glycol and an active derivative thereof provided herein can effectively improve the solubility, stability, and immunogenicity of the drugs, improve the absorption of the drugs in vivo, prolong the half-life of the drugs, and increase bioavailability, enhance efficacy, and reduce toxic and side effects of the drugs. A gel formed from the active derivative of the multi-arm single molecular weight polyethylene glycol provided herein can be used for the preparation of controlled release drugs so as to prolong the action time of the drugs, thereby reducing the number of administrations and improving patient compliance.

Multi-arm single molecular weight polyethylene glycol, active derivative thereof, and preparation and application thereof

The present invention provides a composition of a polyethylene glycol maleimide derivative and a polymerization inhibitor. In particular, the present invention provides a composition of an 8-arm polyethylene glycol maleimide derivative and a phenolic polymerization inhibitor. The ingredient and content of the polymerization inhibitor in the composition are reasonably chosen, thereby significantly increasing stability of the polyethylene glycol maleimide derivative, effectively avoiding the undesirable effect of gel solidifying due to polymerization during storage and transportation, and extending a pot life and shelf life of a product thereof.

Composition of polyethylene glycol maleimide derivative and polymerization inhibitor

The present invention discloses a branched polyethylene glycol epoxy derivative crosslinked sodium hyaluronate gel, preparation and application thereof. The crosslinking agent used in the crosslinked sodium hyaluronate gel prepared by the present invention is a polyethylene glycol epoxy derivative, due to the existence of multiple ether bonds in the molecule of the crosslinking agent, there are more hydrogen bonds in the gel system; meanwhile, due to the particularity of the space structure of the branched polyethylene glycol epoxy derivative, the gel prepared has a more complex winding structure in its space, thus achieving better stability. Moreover, the branched polyethylene glycol epoxy derivative involved in the present invention is a compound with single molecular weight, therefore, the gel prepared thereby has better batch stability.

Branched polyethylene glycol epoxy derivative crosslinked sodium hyaluronate gel, preparation and application thereof

The present invention discloses polyglycol epoxide crosslinked sodium hyaluronate gel for injection and a preparation method thereof. A polyglycol epoxide is a compound with single molecular weight preferably; a plurality of ether bonds are present in the molecule of the polyglycol epoxide, the water solubility is good, and thus, the polyglycol epoxide is more easily subjected to a crosslinking reaction with polysaccharides; and meanwhile, polyglycol is relatively easy in adjustment of the number of repeating units and relatively easy in control of length, and thus, the sodium hyaluronate gel prepared by taking the polyglycol epoxide as a crosslinker is relatively easy in regulation and control of properties. The crosslinked sodium hyaluronate gel is low in toxicity, little in residual, small in squeezing and pushing force, good in shaping performance, good in enzyme resistance and long in in-vivo retention time. The present invention further discloses a mild crosslinker deactivation technology. Unreacted epoxide groups in the gel are subjected to a hydrolysis reaction in a carbonate buffer system with a pH of 8-9, so that the difficulty of impurity removal of the crosslinked sodium hyaluronate gel can be effectively lowered, and the problem of toxicity in the prior art due to the fact that BDDE is used in a crosslinking method is avoided.

Gel of sodium hyaluronate cross-linked by polyethylene glycol epoxy derivative for injection and preparation method thereof

An elevating mechanism is provided in the embodiments of the disclosure, which relates to the technical field of a substrate carrying mechanism device and is capable of decreasing incidence of an electrostatic-breakdown phenomenon of a substrate to be processed during an ascending-descending process thereof. The elevating mechanism is configured to carry the substrate to be processed, including a plurality of struts, each of which is provided at a supporting end thereof with a support portion which is in contact with the substrate to be processed, by means of a supporting surface provided on the support portion when the elevating mechanism carries the substrate to be processed; and an ionic wind supply. Each of the plurality of struts is provided with a channel which is arranged inside a corresponding one of the plurality of the struts and penetrates therethrough and is configured to deliver an ionic wind outputted from the ionic wind supply into the corresponding one of the plurality of struts; and each of the plurality of struts is provided at least at a location of the supporting surface on the support portion with a plurality of first vent holes in communication with the channel thereof, through which the ionic wind delivered by the ionic wind supply is blown towards the substrate to be processed.

Elevating mechanism

A detection device, a substrate holder and a method for detecting a position of a substrate on a substrate holder are disclosed. The detection device of the present disclosure is used to detect the position of the substrate carried on the substrate holder, and the substrate holder includes a plurality of carrying positions, each of which is used to carry a substrate. The detection device includes an emitting electrode connected to a signal source, which is disposed at an edge of each carrying position and located at one of upper and lower sides of the substrate carried by the carrying position; and at least one receiving electrode connected to a detector, which is disposed opposite to the emitting electrode and located at the other of the upper and lower sides of the substrate carried by the carrying position.

Detection device, substrate holder and method for detecting position of substrate on substrate holder

A non-contact probe signal loading device is disclosed. The non-contact probe signal loading device includes a probe metal sheet electrically connected to a signal loading terminal, a lower surface of the probe metal sheet facing towards a signal inputting metal sheet into which a signal is to be loaded. A signal transmitting capacitor is formed between the probe metal sheet and the signal inputting metal sheet, and the signal transmitting capacitor functions as a medium to transmit a loaded signal to the signal inputting metal sheet from the probe metal sheet.

Non-contact probe signal loading device

An array substrate, a manufacturing method thereof and a display device are provided by the present disclosure. The manufacturing method includes: providing a base substrate; forming a plurality of pixel electrodes on the base substrate, in which the operation of forming the plurality of pixel electrodes includes: depositing a first transparent conductive film, and forming the plurality of pixel electrodes and a connection unit for connecting adjacent pixel electrodes by patterning the first transparent conductive film; forming a passivation layer on the plurality of pixel electrodes, and patterning the passivation layer to expose at least a portion of the connection unit; and processing the exposed portion of the connection unit, so that the plurality of interconnected pixel electrodes are electrically insulated.

Array substrate and manufacturing method thereof and display device

The present invention discloses a probe frame for an array substrate detecting apparatus, the probe frame including a frame body and a signal distribution circuit board provided to the frame body, wherein the probe frame further includes: a circuit board provided to the frame body, the circuit board being provided with through holes, and the circuit board being provided therein with a plurality of signal transmission wires in a one to one correspondence with the through holes, one end of each signal transmission wire is inserted into its respective through hole and the other end thereof is electrically connected with an output end of the signal distribution circuit board; and a plurality of probes in a one to one correspondence with the through holes, wherein for each pair of the probe and the through hole, one end of the probe is inserted into the through hole so as to be electrically connected with the signal transmission wire within the through hole. Electrical connection between respective probes and the signal distribution circuit board are achieved through signal transmission wires in the circuit board, wiring on the probe frame is simple, and stability in signal connections between probes and the signal distribution circuit board can be improved. The present invention further provides an array substrate detecting apparatus including the above probe frame.

Probe frame for array substrate detecting apparatus and detecting apparatus having the same

The disclosed technology provides a detection apparatus and its operating method. The disclosed technology provides a detection apparatus, comprising: a test chamber, an exchange chamber, and a communicating mechanism, which is provided between the test chamber and the exchange chamber and capable of rendering the test chamber and the exchange chamber separated from or communicated with each other; wherein transmission devices are positioned within the test chamber and the exchange chamber, respectively, and the transmission devices are adapted to convey a probe frame from the test chamber to the exchange chamber or from the exchange chamber to the test chamber.

Growing community of inventors

Beijing, China

Zhen Wei