Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Zhen Li

Sander G Mills

Jeffrey John Hale

George A Doherty

James B Doherty

Soumya P Sahoo

Christopher L Lynch

Joseph S Amato

James A McCauley

Meng-Hsin Chen

Weirong Chen

Swaminathan R Natarajan

William E Neway, Iii

Veena Upadhyay

Ann Decamp

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation. 

P38 kinase inhibiting agents

The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included. 

N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists

The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists

A crystalline pharmaceutically acceptable benzenesulfonate salt of Compound A of formula:

Crystalline pharmaceutically acceptable salts of an oxazolidinone derivative

Process for making intermediate aldehydes

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Scotch Plains, NJ, United States of America

Zhen Li