Cytokinetics, Inc.

Zhe Yang

Bradley Paul Morgan

Gustave Bergnes

Scott E Collibee

Alex R Muci

Xiangping Qian

Chihyuan Chuang

Jeffrey Warrington

Pu-Ping Lu

Luke W Ashcraft

Antonio Romero

Jeff Gardina

Jianchao Wang

David John Morgans, Jr

Brian M Stoltz

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and mare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Amino-pyrimidine skeletal muscle modulators

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Substituted pyridazines as skeletal muscle modulators

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, X, Z, Z, Z, Zand m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use

Certain heterocycles, compositions thereof, and methods for their use

Amino-pyridazine skeletal muscle modulators

Certain amino-pyrimidines, compositions thereof, and methods for their use

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.

Certain chemical entities, compositions, and methods

Certain 3,5-dibenzoyl-4-phenyl-piperidine compounds and salts thereof are provided herein. The compounds and salts may be useful in causing mitotic arrest and cell death. Also provided herein are certain pharmaceutical compositions comprising 3,5-dibenzoyl-4-phenyl-piperidine compounds or salts thereof and certain methods of use thereof.

3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds

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Daly City, CA, United States of America

Zhe Yang