Hong Kong Baptist University

Yunnan Minzu University

Other

Shanghai University of Traditional Chinese

Changshu Hkbu Technology Company Limited

Yunnan University of Nationalities

Zhaoxiang Bian

Aiping Lu

Chengyuan Lin

Dajian Yang

Shilin Chen

Hongxi Xu

Albert Sun Chi Chan

Albert Sun-Chi Chan

Huaixue Mu

Siu Wai Tsang

Baomin Fan

Kaixian Chen

Yongyun Zhou

Hongjie Zhang

Hong Jie Zhang

Sun Chi Albert Chan

Qingjing Yang

Zhijun Yang

Jingchao Chen

Yuanzhi Lao

Xiaoyu Wang

Jun Wang

Quanbin Han

Xin Li

Yegao Chen

Chao Huang

Aiping Lyu

Jianbin Xu

Jun Hu

Haitao Xiao

Hongyan Qin

Guoqing Chen

Zihao Wang

Ling Zhao

Lidan Zhong

Tao Hung

Ruihong Gong

Che Yuen Justin Wu

Siu Po Ip

Weimin Zeng

Yue Lv

Linfang Huang

Tao Huang

Hongsheng Tan

Jinjin Wang

Xiaoyu Chen

Blenda Chi Kwan Wong

Wenwei Fu

A method of treating a glucose-6-phosphate dehydrogenase deregulated disorder in a subject in need thereof, the method involving administering a therapeutically effective amount of oleanolic acid or a conjugate salt thereof or prodrug thereof to the subject. The glucose-6-phosphate dehydrogenase deregulated disorder can be BCL2 associated athanogene myofibrillar myopathy, amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, or Alzheimer disease.

Identification of oleanolic acid and plant extract for glucose-6-phosphate dehydrogenase-related disorders including Bag3opathy

Provided herein are compounds useful in the treatment of inflammatory diseases, pharmaceutical compositions comprising the same, and methods of use and preparation thereof. The compounds exhibit inhibitory effects on the expression and secretion of pro-inflammatory cytokines, such as IL-1β, IL-6 and TNF-α.

Flavan-3-ol analogs and anti-inflammatory activity

Provided is a combined pharmaceutical composition of HF and ansesquiterpene lactone compound for treating cancers. The active ingredients of the combined pharmaceutical composition consist of HF and ansesquiterpene lactone compound. HF and ATS have significant synergistic effect. The activity of the combined pharmaceutical of HF and ATS is comparable or even higher than that of the anti-cancer drug 5-FU.

Anti-cancer composition consisting of halofuginone and sesquiterpene lactone compounds of artemisia apiacea and use thereof

Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.

Identification of cyclic peptide agonists of galanin receptor 2 and 3 guided by spexin solution structure

The present invention relates to an atom economic procedure of preparing iodoalkanes by hydroiodination of alkenes. In particular the present method features the generation of anhydrous hydrogen iodide from atomic hydrogen and iodine in situ by using transition metal precursor and phosphine ligandcatalyst.

Method for the preparation of iodoalkanes

The present invention provides a slow and controlled released liposomal gel composition for subcutaneous administration comprises insulin or exenatide as active ingredient for reduction of blood sugar level and method of preparation thereof. Said controlled released composition has high bioavailability and is demonstrated to be able to sustain release therapeutically effective concentration of drug over a period of time and without rapid release of drug after initial administration. Method of preparing the controlled released composition of the present invention comprises the following steps: mixing insulin or exenatide, lipid and aqueous dispersion medium together; then mixing with poloxamer (e.g. F127 or P123) and/or gelatin and hyaluronic acid (HA) or the like gel solution so as to form a protective layer on surface of every lipid micro vesicles or nano-vesicles for use in intramuscular, abdominal and subcutaneous administration. A single administration of the present composition lasts 2 to 7 days to reduce side-effects, such as pain and irritation.

Slow and controlled released liposomal gel composition comprising hypoglycemic active ingredient and method of preparing thereof

A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or prodrug thereof for inhibiting Syk activity, 

Method for preventing and/or treating a subject suffering from asthma

This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.

Palladium/silver co-catalyzed tandem reactions synthesis of phenylacetophenone derivatives by oxabenzonorbornadienes with terminal alkynes and their anti-tumor or anti-cancer activities

The present invention relates to chemical constituents of the hydro-alcoholic extract of root of(L.) Thwait. More particularly, it relates to the bioactive chemical composition of(L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.

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The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root ofLinn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.

Anti-esophageal cancer compound and method of use thereof

The present invention relates to a method of using trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury

The present invention provides a compound, namely (+)-3'-Angeloyloxy-4&#x2032;-keto-3&#x2032;,4&#x2032;-dihydroseselin (Pd-Ib) derived fromas the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.

(+)-3'-angeloyloxy-4&#x2032;-keto-3&#x2032;,4&#x2032;-dihydroseselin for treating inflammation

Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I):  More particularly, it relates to said anti-prostate cancer compound that can be isolated fromor chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.

Pharmaceutical composition comprising guttiferone F for the treatment of prostate cancer

Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.

Anti-cervical cancer compound and method of use thereof

A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from

Use of a flavanol glycoside for suppressing activation of stellate cells

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Hong Kong, China

Zhaoxiang Bian