National Institute of Biological Sciences, Beijing

Sironax Ltd.

Zhaolan Zhang

Li Li

Xiaodong Wang

Zhiyuan Zhang

Shaoqiang Huang

Jianguang Han

Xian Jiang

Yaning Su

Yanping Xu

Provided are piperazine cyclic urea compounds that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), pharmaceutically acceptable salts, hydrates and stereoisomers thereof. Provided are also pharmaceutical compositions, methods of making, and methods of use which include treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Piperazine cyclic ureas

The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

Apoptosis inhibitors

Growing community of inventors

Beijing, China

Zhaolan Zhang