Quest Diagnostics Investments, Inc.

Zhaohui Chen

Nigel J Clarke

Richard E Reitz

Michael McPhaul

Stephen W Taylor

Steven W Taylor

Michael Mcphual

Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Quantitation of insulin by high resolution/high accuracy mass spectrometry using the 6+ multiply charged insulin ion

Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

C peptide detection by mass spectrometry

Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Methods for quantitation of insulin levels by mass spectrometry

Quantitation of insulin by mass spectrometry of insulin A chain

Quantitation of insulin by tandem mass spectrometry of insulin B chain

Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. The present invention provides methods for detecting the presence or amount of C peptide in a sample by mass spectrometry.

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Las Flores, CA, United States of America

Zhaohui Chen