Microdose Therapeutx, Inc.

Epix Pharmaceuticals, Inc.

Collagen Medical, LLC

Epix Medical, Inc.

Cytopathfinder, Inc.

Factor 1a, LLC

Zhaoda Zhang

Peter Caravan

Andrew Kolodziej

Stephane A Dumas

Sharon Shacham

Vincent Jacques

Yael Marantz

Dilara McCauley

Oren Becker

Ashis K Saha

Thomas J McMurry

Pini Orbach

Efrat Ben-Zeev

Aaron Sato

Jian Lin

Richard J Looby

John C Amedio, Jr

Aida Abujoub

Wei-Chuan Sun

Steffi K Koerner

A Sekar Reddy

David R Buckler

Biplab Kumar Das

Michael Xie

Shomir Ghosh

Victor J Cee

Xiang Y Yu

Brian Alan Lanman

Randall B Lauffer

Jennifer Elizabeth Golden

Srinivasa Rao Cheruku

Roland W Burli

Silvia Noiman

Dongli Chen

Susana C Neira

Mercedes Lobera

Pradyumna Mohanty

Anurag Sharadendu

Steffi Koerner

Merav Fichman

Nili Schutz

Kimberley Gannon

John Amedio

Robert Christian Penland

Rosa E Melendez

Xifang Wang

Alexander L Nivorozhkin

Shrikumar Nair

Peter D Caravan

Thomas J Mcmurry

Stephane Dumas

John C Amedio

Dilara Mccaulay

Roland Burli

Susana Neira

Robert C Penland

Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.

Methods for collagen imaging

Provided are adenosine analog compounds such as that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.

Adenosine analogs and their use

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer. 

Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. 

Carboxamide compounds and their use

Methods of collagen imaging

Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.

Peptide-based multimeric targeted contrast agents

The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Beh&#xe7;et's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

S1P receptor modulating compounds and use thereof

Targeting multimeric imaging agents through multilocus binding

Growing community of inventors

Andover, MA, United States of America

Zhaoda Zhang