Medshine Discovery Inc.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Cstone Pharmaceuticals

Cstone Pharmaceuticals Co., Ltd.

Zhaobing Xu

Charles Z Ding

Shuhui Chen

Lihong Hu

Jian Li

Guoping Hu

Yingchun Liu

Yaxian Cai

Hailong Yang

Shiqi Han

Fei Wang

Xiquan Zhang

Weidong Li

Rui Zhao

Zongbin Li

Baoping Zhao

Ruibin Lin

Bingjie Ren

Xingxun Zhu

Provided are a class of KRAS G12C mutein inhibitors, which relate in particular to a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof. 

Pyridone-pyrimidine derivative acting as KRAS G12C mutein inhibitor

Pyridone-pyrimidine derivative acting as KRASG12C mutein inhibitor

Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer. 

SMAC mimetics used as IAP inhibitors and use thereof

Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers. 

1,6-naphthyridine derivatives as CDK4/6 inhibitor

A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like. 

Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor

Disclosed is a substituted 2H-pyrazole derivative serving as a selective CDK4/6 inhibitor. Specifically, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof which serves as a selective CDK4/6 inhibitor. 

Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug

Growing community of inventors

Shanghai, China

Zhaobing Xu