University of Tennessee Research Foundation

Gtx Corporation

The Ohio State University

Zhao Wang

Wei Li

Duane Douglas Miller

James T Dalton

Jianjun Chen

Chien-Ming Li

Yan Lu

Sunjoo Ahn

Charles B Duke

Li Wei

The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

Compounds for treatment of cancer

Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O&#x2550;, S&#x2550;, &#x2550;N&#x2014;NH, &#x2550;N&#x2014;OH, or &#x2014;OH; Y is optional and can be &#x2014;N(H)&#x2014;, O, or Cto Chydrocarbon; and Rand Rare each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

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Downingtown, PA, United States of America

Zhao Wang