Shaanxi Panlong Pharmaceutical Co., Ltd.

Other

Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd.

Zhao Ma

Chengyuan Liang

Dezhu Zhang

Xiaolin Xie

Xuhua Zhou

Lei Tian

Jingyi Li

Liang Xin

Kangxiong Wu

Shaojun Zhang

Han Li

Xuechuan Wang

Taotao Qiang

Juan Xia

Nan Qin

Xiuding Yang

Zhenfeng Shi

Yuting Liu

Qingbo Zhao

Min Li

Catherine J Lee

Maggie Lewis

Sundian Liu

Yuzhi Liu

Mingjia Li

Yang Xu

Jianguo Meng

Zhong Meng

Bo Jin

Boyang Li

Fan Yuan

Shujun Ding

Mengjie Li

Zhanbin Liu

The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.

3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and preparation method and use thereof

A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.

Polygoni Milletii Rhizome compositions and methods of preparing the same

Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R, R, Rand Rare independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; Ris a hydrogen or halogen; and Ris hydrogen, C1-4 alkane or C1-4 cycloalkane.

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

The present disclosure discloses a two-layered varied ball diameter packed bed heat storage apparatus and a method of manufacturing a heat storage ball. By arranging large-diameter heat storage balls at an upper layer of a packed bed heat storage apparatus and small-diameter heat storage balls at a lower layer thereof; the packed bed heat storage structure comprehensively considers two important evaluation indicators for a heat storage apparatus: heat storage rate and heat storage density, thereby implementing a design principle of maximizing the heat storage rate density of the packed bed heat storage apparatus; by achieving a best combination of heat storage ball diameters inside the packed bed through an optimized design, the heat storage apparatus is imparted with a best heat storage performance. The present disclosure further provides a method of manufacturing a heat storage ball.

Two-layer variable-diameter packed bed heat storage apparatus and heat storage ball preparation method

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Xi'an, China

Zhao Ma