Chinese Academy of Sciences

Jinan University

Shanghai Haihe Pharmaceutical Co., Ltd.

Shenzhen Newdel Biotech Co., Ltd.

Huawei Technologies Co., Limited

Haihe Biopharma Co., Ltd.

Zhang Zhang

Dongmei Zhang

Zhe Liu

Jian Ding

Jinlin Peng

Yongzhao Cao

Meiyu Geng

Fan Wang

Ke Ding

Jie Wang

Jing Ai

Xia Peng

Zhengchao Tu

Xiaoyun Lu

Duanqing Pei

Yinchun Ji

Li Tan

Xiaomei Ren

Zhenwei Li

Zhi Li

Feng Jin

Yang Dai

Shuihua Zhang

Xun He

Shingpan Chan

Deping Wang

Mengjie Shen

Kun Luo

Yubing Feng

Shuang Xiang

Donglin Gao

Zhimin Zhang

Xia Tang

Zuqin Wang

The present disclosure relates to Alkynylphenylbenzamide compounds and the applications thereof. The said Alkynylphenylbenzamide compounds have the structure shown in Formula (I). The compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of TRK protein kinase and the proliferation, migration and invasion of various tumor cells. At the same time, it has the characteristics of good pharmacokinetics and low toxicity.

Alkynylphenylbenzamide compounds and applications thereof

Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells; and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.

Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof

The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec. 

Heterocyclic alkynyl benzene compounds and medical compositions and uses thereof

Growing community of inventors

Guangdong, China

Zhang Zhang