Arcus Biosciences, Inc.

Zhang Wang

Manmohan Reddy Leleti

Guillaume Mata

Jaroslaw Kalisiak

Xuelei Yan

Brandon Reid Rosen

Kenneth Victor Lawson

Joel Worley Beatty

Jenna Leigh Jeffrey

Samuel Lawrie Drew

Balint Gal

Artur Karenovich Mailyan

Clayton Hardman

Kai Yu

Matthew Epplin

Hyunyoung Moon

Karl T Haelsig

Jay Patrick Powers

Debashis Mandal

Erick Allen Lindsey

Yongli Su

Anh Thu Tran

Steven Donald Jacob

Tezcan Guney

Jeremy Thomas Andre Fournier

Jeremy Fournier

Srinivas Paladugu

Jiang Zhu

Karen Yir Jing Chen

Pradeep Nareddy

Monika Yadav

Manjunath Lamani

Srijita Bhowmik

The present disclosure is directed to compounds having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Thiazole compounds and methods of use thereof

The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.

Process for preparing tetralin compounds

Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha

Compounds that inhibit HIF-2&#x3b1;, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2&#x3b1;.

Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2&#x3b1;

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Petaluma, CA, United States of America

Zhang Wang