Beijing Normal University

Beijing Shihong Pharmaceutical Research Center

Zhanbin Zhang

Junbo Zhang

Xuebin Wang

Jie Lu

Zhigang Tang

Qing Ruan

Xuran Zhang

Qianqian Gan

Xin Shao

Yuhao Jiang

Qianna Wang

Guangxing Yin

A mannose derivative is an isonitrile-containing mannose derivative of formula (I), including different linking groups X: A radioactive preparation is provided, including a radiolabeled compound formed by radiolabeling the mannose derivative with a radionuclide. An application of the radioactive preparation in the diagnosis and treatment of tumors is also provided.

Mannose derivative and application thereof

Disclosed herein is a benzene ring-containing glucose derivative of formula (I): where Ris each independently and Ris hydrogen. This application also provides a radioactive drug, including a complex formed by the benzene ring-containing glucose derivative and a radionuclide. Use of the benzene ring-containing glucose derivative in the tumor treatment and diagnosis is further provided.

Benzene ring-containing glucose derivative and use thereof

ATc-labeled isonitrile-containing glucose derivative having the general formula [Tc-(CNDG)], preparation method and use thereof is disclosed herein. The derivative is centered onTc, and the carbon atom of the isonitrile in CNDG coordinates withTc(I) to form a hexacoordinated complex [Tc-(CNDG)]. The [Tc-(CNDG)]derivative was obtained by the synthesis of the ligand CNDG and the preparation of the lyophilized CNDG kit. The derivative of this disclosure has good stability, simple preparation, high uptake and good retention at a tumor site, and high tumor/non-target ratio, and it is a novelTc-labeled isonitrile-containing glucose derivative with excellent performance for tumor imaging. The derivative of this disclosure is advantageous for popularization and application.

Tc-labeled isonitrile-containing glucose derivative and preparation method and use thereof

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Beijing, China

Zhanbin Zhang