International Business Machines Corporation

Agency for Science, Technology and Research

Zhan-Yuin Ong

James L Hedrick

Yi Yan Yang

Amanda Catherine Engler

Daniel Joseph Coady

Victor W L Ng

Richard Anthony Dipietro

Ashlynn L Z Lee

Jeremy P K Tan

Willy Chin

Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Antimicrobial cationic polycarbonates

Growing community of inventors

Singapore, Singapore

Zhan-Yuin Ong