National Institutes of Health, a Component of the US Dept. of Health & Human Services

Universiteit Leiden

Zhan-Guo Gao

Kenneth Alan Jacobson

Adriaan Pieter Ijzerman

Johannes Brussee

Anikó Göblyös

Aniko Goblyos

The claimed subject matter relates to allosteric modulation of Aadenosine receptor (AAR) and provides for the use of an Aadenosine receptor modulator (ARM), for the preparation of pharmaceutical compositions for modulating the AAR in a subject, as well as pharmaceutical compositions including the same and therapeutic methods including administering to a subject an amount of an ARM, the amount being effective to modulate AAR activity. The ARM according to claimed subject matter are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. Also provided are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.

A3 adenosine receptor allosteric modulators

The present invention relates to allosteric modulation of Aadenosine receptor (AAR) and provides for the use of an Aadenosine receptor modulator (ARM), for the preparation of pharmaceutical compositions for modulating the AAR in a subject, as well as pharmaceutical compositions comprising the same and therapeutic methods comprising administering to a subject an amount of an ARM, the amount being effective to modulate AAR activity. The ARM according to the invention are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. The invention also provides some of such novel 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.

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Rockville, MD, United States of America

Zhan-Guo Gao