Fudan University

Chinese Academy of Sciences

Shanxi Jinbo Bio-pharmaceutical Co., Ltd.

Zezhong Liu

Shibo Jiang

Lu Lu

Jie Zhou

Qian Wang

Xia Yang

Yang Qiu

Jingfang Mu

Yuan Fang

Xi Zhou

Zhenrui He

Chengfeng Qin

Provided are a fusion protein and use thereof. Provided is a fusion protein, comprising a trimerization block and an immunogenic block which are connected by a linker, wherein the trimerization block comprises one or more of repeat units set forth in SEQ ID NO. 1; the immunogenic block is an immunogenic protein of a pathogen, for example, being selected from a coronavirus RBD block, an HIV membrane protein or an influenza virus hemagglutinin protein, and immunogenic fragments thereof. Compared with an immunogen monomer, the trimer can generate a higher neutralizing antibody level, does not induce a strong antibody against the trimerization block in a human body, and can promote the immune response of the organism to be focused on the immunogenic block.

Fusion protein and use thereof

Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.

Broad-spectrum polypeptide against enterovirus and application thereof

Growing community of inventors

Shanghai, China

Zezhong Liu