Shenzhen Pharmacin Co., Ltd.

Zeren Wang

Shun Chen

Jun Xu

Yulan Zhao

Xiao Zhang

Shunqin Chen

Long Qu

Lijiang Wang

Meili Sun

Guisheng Jiang

Longwei Sun

Yanxin Zhao

Jiqian Peng

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). Provided are pharmaceutical compositions which include a mixture of a PROTAC, a hydrophilic polymer, a surfactant, and optionally an acid and an adsorbent. Also described are methods for preparing and using such pharmaceutical compositions. In one aspect, disclosed herein is an amorphous solid dispersion comprising PROTAC.

Pharmaceutical compositions of PROTAC compounds and uses thereof

Provided are pharmaceutical compositions which include a mixture of a lipophilic active pharmaceutical ingredient such as nilotinib, a hydrophilic polymer, one or more surfactants, and optionally an adsorbent. Also described are methods for preparing and using such pharmaceutical compositions. In one aspect, disclosed herein is an amorphous solid dispersion comprising the active pharmaceutical ingredient.

Pharmaceutical compositions

The present invention provides an oral pharmaceutical composition and a usage thereof, comprising a pharmaceutically acceptable acidic medicinal auxiliary material whose surface is modified and dabigatran etexilate or pharmaceutically acceptable salts or aquo-complexes thereof. The present invention further provides a surface modification method for a medicinal auxiliary material.

Pharmaceutical composition and preparation method therefor

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Shenzhen, China

Zeren Wang